相互作用
Brigatinib + Efavirenz
重症度: 重大
Brigatinib and Efavirenz: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Efavirenz can lower brigatinib exposure through CYP3A induction, potentially reducing its anti-tumor effect in ALK-positive lung cancer.
この相互作用をわかりやすく説明すると
Brigatinib and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brigatinib belongs to Oncology; Efavirenz belongs to Anti Virals.
なぜ起こるのか
Efavirenz induces CYP3A4, accelerating brigatinib metabolism.
対処法
Avoid the combination and use a non-inducing antiretroviral. If a strong or moderate inducer is unavoidable, the brigatinib dose may need to be increased per labeling with close monitoring of response and tolerability.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BrigatinibとEfavirenzの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Efavirenzのその他の相互作用
Brigatinibのその他の相互作用
よくある質問
Can I take Brigatinib with Efavirenz?
MediHelp rates the interaction as major. Brigatinib and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz can lower brigatinib exposure through CYP3A induction, potentially reducing its anti-tumor effect in ALK-positive lung cancer.
How serious is the interaction between Brigatinib and Efavirenz?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing antiretroviral. If a strong or moderate inducer is unavoidable, the brigatinib dose may need to be increased per labeling with close monitoring of response and tolerability.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
