相互作用
Apalutamide + Brigatinib
重症度: 重大
Apalutamide and Brigatinib: major interaction.
最終更新日
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概要
Brigatinib is metabolized mainly by CYP3A4, and apalutamide strongly induces this enzyme. Lower brigatinib exposure may reduce efficacy in ALK-positive lung cancer.
この相互作用をわかりやすく説明すると
Apalutamide and Brigatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Brigatinib belongs to Oncology.
なぜ起こるのか
Apalutamide induces CYP3A4, increasing brigatinib clearance.
対処法
Avoid concurrent use. If unavoidable, increase the brigatinib dose per labeling guidance for strong inducers and monitor response.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApalutamideとBrigatinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Apalutamideのその他の相互作用
Brigatinibのその他の相互作用
よくある質問
Can I take Apalutamide with Brigatinib?
MediHelp rates the interaction as major. Apalutamide and Brigatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brigatinib is metabolized mainly by CYP3A4, and apalutamide strongly induces this enzyme. Lower brigatinib exposure may reduce efficacy in ALK-positive lung cancer.
How serious is the interaction between Apalutamide and Brigatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If unavoidable, increase the brigatinib dose per labeling guidance for strong inducers and monitor response.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
