医薬品リファレンス
Cefiderocol
Cefiderocol is a medicine in the class anti bacterial. It is used for pneumonia.
- 薬効分類: Anti Bacterial
- 効能・効果: pneumonia
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Anti Bacterial
- 一般的な剤形
- 注射剤
- 一般的な規格
- 1 g/10 ml
- 既知の相互作用
- 5 (中等度: 3 · 軽度: 2)
- 商品名
- 2
- 国・市場
- 2
何に使われるか
作用のしくみ
Cefiderocol is a siderophore cephalosporin. It binds extracellular free iron and is actively transported into the periplasmic space of Gram-negative bacteria, then binds penicillin binding proteins, inhibiting peptidoglycan cell wall synthesis and causing cell lysis and death.
成人の通常用量（添付文書の要約）
cUTI and HABP/VABP (CLcr 60 to 119 mL/min): 2 grams IV infusion over 3 hours every 8 hours; duration 7 to 14 days guided by clinical status
妊娠と授乳
- 妊娠
- Safe No human data; animal studies showed no embryo-fetal toxicity. Cephalosporins as a class have not shown birth-defect risk. Use when needed for resistant infections with limited options.
- 授乳
- Safe No human milk data; found in rat milk. LactMed: cephalosporins are not expected to harm breastfed infants, so it is acceptable; watch for loose stools or thrush.
報告されている副作用
- Diarrhea
- Infusion site reactions
- Constipation
- Rash
- Elevated liver tests
- Hypokalemia
禁忌
- Known history of severe hypersensitivity to cefiderocol, other beta-lactam antibacterials, or any component of FETROJA
注意が必要な方
- Increased all-cause mortality vs best available therapy in patients with carbapenem-resistant Gram-negative infections; monitor clinical response closely
- Serious and occasionally fatal hypersensitivity reactions; ask about prior beta-lactam allergy; discontinue if allergic reaction occurs
- Clostridioides difficile-associated diarrhea may range from mild diarrhea to fatal colitis
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (5)
- Amikacin + Cefiderocol Moderate
- Cefiderocol + Streptomycin Moderate
- Cefiderocol + Warfarin Moderate
- Cefiderocol + Dexamethasone-tobramycin Minor
- Cefiderocol + Gentamicin Minor
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Cefiderocolの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Cefiderocol used for?
Cefiderocol is a medicine in the class anti bacterial. It is used for Pneumonia, Pyelonephritis, Urinary tract infections.
What side effects have been reported with Cefiderocol?
Diarrhea, Infusion site reactions, Constipation, Rash, Elevated liver tests, Hypokalemia.
Can Cefiderocol be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. No human data; animal studies showed no embryo-fetal toxicity. Cephalosporins as a class have not shown birth-defect risk. Use when needed for resistant infections with limited options. Breastfeeding: Safe. No human milk data; found in rat milk. LactMed: cephalosporins are not expected to harm breastfed infants, so it is acceptable; watch for loose stools or thrush.
What does Cefiderocol interact with?
MediHelp lists 5 known interactions for Cefiderocol. Moderate: 3 · Minor: 2. The most serious include Amikacin, Streptomycin, Warfarin.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
