医薬品リファレンス
Cefepime
Cefepime is a medicine in the class anti bacterial. It is used for febrile neutropenia.
- 薬効分類: Anti Bacterial
- 効能・効果: febrile neutropenia
最終更新日 出典: US FDA label, CIMA AEMPS (Spain), AEMPS CIMA ficha tecnica (Spanish)
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このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Anti Bacterial
- 一般的な剤形
- 注射剤
- 一般的な規格
- 1 g, 2 g, 500 mg
- 既知の相互作用
- 22 (中等度: 12 · 軽度: 10)
- 商品名
- 47
- 国・市場
- 4
何に使われるか
作用のしくみ
Fourth-generation cephalosporin; has gram-negative coverage comparable to ceftazidime but better gram-positive coverage (comparable to ceftriaxone); is zwitterion and rapidly penetrates gram-negative cells; is best beta-lactam for IM administration; has poor capacity to cross blood-brain barrier and thus is not used for treatment of meningitis
成人の通常用量（添付文書の要約）
Pneumonia : 1-2 g IV q8-12hr for 7-10 days (if not caused by Pseudomonas) or for up to 21 days (if caused by Pseudomonas)
妊娠と授乳
- 妊娠
- Safe Cephalosporins are widely used in pregnancy, and available data show no increase in birth defects; animal studies showed no harm. Considered a safe choice for serious infections.
- 授乳
- Safe Passes into milk in low amounts. Compatible with breastfeeding; watch the infant for loose stools, rash or thrush.
報告されている副作用
- Diarrhea
- Rash
- Positive Coombs test result without hemolysis
- Elevated alanine aminotransferase
- Hypophosphatemia
禁忌
- Documented hypersensitivity to cefepime, penicillins, or other beta-lactam antibiotics
注意が必要な方
- If CrCl <60 mL/min, adjust dosage to compensate for slower renal elimination rate
- Caution warranted with history of previous immediate hypersensitivity reactions to cefepime, cephalosporins, penicillins, or other drugs
- Prescribing drug in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to patient
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (22)
- Amikacin + Cefepime Moderate
- Cefepime + Cholera vaccine Moderate
- Cefepime + Dexamethasone-tobramycin Moderate
- Cefepime + Gentamicin Moderate
- Cefepime + Kanamycin Moderate
- Cefepime + Microbiota Moderate
- Cefepime + Plazomicin Moderate
- Cefepime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Cefepime + Streptomycin Moderate
- Cefepime + Tobramycin Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Cefepimeの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Cefepime used for?
Cefepime is a medicine in the class anti bacterial. It is used for Febrile neutropenia, Intra-abdominal infections, Pneumonia, Sepsis, Skin infections, Urinary tract infections.
What side effects have been reported with Cefepime?
Diarrhea, Rash, Positive Coombs test result without hemolysis, Elevated alanine aminotransferase, Hypophosphatemia.
Can Cefepime be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Cephalosporins are widely used in pregnancy, and available data show no increase in birth defects; animal studies showed no harm. Considered a safe choice for serious infections. Breastfeeding: Safe. Passes into milk in low amounts. Compatible with breastfeeding; watch the infant for loose stools, rash or thrush.
What does Cefepime interact with?
MediHelp lists 22 known interactions for Cefepime. Moderate: 12 · Minor: 10. The most serious include Amikacin, Cholera vaccine, Dexamethasone-tobramycin.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
