医薬品リファレンス
Epirubicin
Epirubicin is a medicine in the class oncology. It is used for breast cancer.
- 薬効分類: Oncology
- 効能・効果: breast cancer
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- 一般的な剤形
- 注射剤, 点滴静注剤
- 一般的な規格
- 10 mg/5 ml, 50 mg/25 ml, 50 mg
- 既知の相互作用
- 23 (併用禁忌: 1 · 重大: 11 · 中等度: 9 · 軽度: 2)
- 商品名
- 26
- 国・市場
- 4
何に使われるか
作用のしくみ
Anthracycline; intercalates between DNA base pairs and triggers cleavage by topoisomerase II, which results in cytocidal activity. Inhibits DNA helicase and generates cytotoxic free radicals.
成人の通常用量（添付文書の要約）
Adjuvant Breast Cancer Treatment: Day 1: Epirubicin 100 mg/m² IV, AND 5-fluorouracil 500 mg/m² IV, AND cyclophosphamide 500 mg/m² IV
妊娠と授乳
- 妊娠
- Unsafe Can cause fetal harm; avoid in the 1st trimester. Fetal and newborn heart toxicity has been reported after exposure. Any later use for cancer needs specialist care. Women: effective contraception during and for 6 months after the last dose.
- 授乳
- Unsafe No human milk data; present in rat milk. Do not breastfeed during treatment and for at least 7 days after the last dose (LactMed: at least 8 days, based on half-life).
報告されている副作用
- Vomiting
- Nausea
- Leukopenia
- Anemia
- Neutropenia
- Alopecia
注意が必要な方
- Administration of live or live-attenuated vaccines in patients immunocompromised by chemotherapeutic agents may result in serious or fatal infections
- Administration after previous radiation therapy may induce an inflammatory recall reaction at site of irradiation
- Therapy can cause fetal harm; advise patients of potential risk to a fetus and to use effective contraception
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (23)
- Adenovirus types 4 and 7 live + Epirubicin Contraindicated
- Belatacept + Epirubicin Major
- Cimetidine + Epirubicin Major
- Deferiprone + Epirubicin Major
- Dengue vaccine + Epirubicin Major
- Epirubicin + Etrasimod Major
- Epirubicin + Fingolimod Major
- Epirubicin + Ropeginterferon alfa 2b Major
- Epirubicin + Siponimod Major
- Epirubicin + Tofacitinib Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Epirubicinの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Epirubicin used for?
Epirubicin is a medicine in the class oncology. It is used for Breast cancer.
What side effects have been reported with Epirubicin?
Vomiting, Nausea, Leukopenia, Anemia, Neutropenia, Alopecia.
Can Epirubicin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm; avoid in the 1st trimester. Fetal and newborn heart toxicity has been reported after exposure. Any later use for cancer needs specialist care. Women: effective contraception during and for 6 months after the last dose. Breastfeeding: Unsafe. No human milk data; present in rat milk. Do not breastfeed during treatment and for at least 7 days after the last dose (LactMed: at least 8 days, based on half-life).
What does Epirubicin interact with?
MediHelp lists 23 known interactions for Epirubicin. Contraindicated: 1 · Major: 11 · Moderate: 9 · Minor: 2. The most serious include Adenovirus types 4 and 7 live, Belatacept, Cimetidine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
