医薬品リファレンス
Idarubicin
Idarubicin is a medicine in the class oncology. It is used for leukemia.
- 薬効分類: Oncology
- 効能・効果: leukemia
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- 一般的な剤形
- 注射剤, 溶液
- 一般的な規格
- 1 mg/ml, 5 mg, 5 mg/5 ml
- 既知の相互作用
- 41 (併用禁忌: 1 · 重大: 11 · 中等度: 22 · 軽度: 7)
- 商品名
- 7
- 国・市場
- 4
何に使われるか
作用のしくみ
Anthracycline; intercalates between DNA base pairs, inhibits topoisomerase II, which in turn inhibits DNA and RNA synthesis
成人の通常用量（添付文書の要約）
Acute Myeloid Leukemia: Induction: 12 mg/m² IV qDay over 10-15 min for 3 day with concomitant cytarabine
妊娠と授乳
- 妊娠
- Unsafe Cytotoxic anthracycline: embryotoxic and teratogenic in rats at a tenth of the human dose; it can harm the fetus. Avoid, especially in the 1st trimester; any later use for leukaemia needs specialist care. Contraception: women during and for 6.5 months after; men 3.5 months.
- 授乳
- Unsafe Not known whether it passes into milk. US label: do not breastfeed during treatment and for 14 days after the last dose (risk of low blood counts, heart toxicity and cancer in the infant); LactMed agrees, given the long half-life of its active metabolite.
報告されている副作用
- Vomiting
- Nausea
- Alopecia
- Infection
- Fever
- Hemorrhage
注意が必要な方
- Prior radiation treatment to mediastinal-pericardial area & prior anthracyclines increases cardiotoxic risk
- Cumulative doses >150 mg/m² associated with decreased ejection fraction
- Possibility of injection site reactions
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (41)
- Adenovirus types 4 and 7 live + Idarubicin Contraindicated
- Belatacept + Idarubicin Major
- Cyclophosphamide + Idarubicin Major
- Deferiprone + Idarubicin Major
- Dengue vaccine + Idarubicin Major
- Etrasimod + Idarubicin Major
- Fingolimod + Idarubicin Major
- Idarubicin + Ofatumumab sc Major
- Idarubicin + Ropeginterferon alfa 2b Major
- Idarubicin + Siponimod Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Idarubicinの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Idarubicin used for?
Idarubicin is a medicine in the class oncology. It is used for Leukemia.
What side effects have been reported with Idarubicin?
Vomiting, Nausea, Alopecia, Infection, Fever, Hemorrhage.
Can Idarubicin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Cytotoxic anthracycline: embryotoxic and teratogenic in rats at a tenth of the human dose; it can harm the fetus. Avoid, especially in the 1st trimester; any later use for leukaemia needs specialist care. Contraception: women during and for 6.5 months after; men 3.5 months. Breastfeeding: Unsafe. Not known whether it passes into milk. US label: do not breastfeed during treatment and for 14 days after the last dose (risk of low blood counts, heart toxicity and cancer in the infant); LactMed agrees, given the long half-life of its active metabolite.
What does Idarubicin interact with?
MediHelp lists 41 known interactions for Idarubicin. Contraindicated: 1 · Major: 11 · Moderate: 22 · Minor: 7. The most serious include Adenovirus types 4 and 7 live, Belatacept, Cyclophosphamide.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
