相互作用
Bupropion + Deutetrabenazine
重症度: 重大
Bupropion and Deutetrabenazine: major interaction.
最終更新日
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概要
Bupropion is a strong CYP2D6 inhibitor and markedly raises exposure to the active metabolites of deutetrabenazine. This increases the risk of sedation, akathisia, parkinsonism, depression and QT prolongation.
この相互作用をわかりやすく説明すると
Bupropion and Deutetrabenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion belongs to Central Nervous System; Deutetrabenazine belongs to Central Nervous System.
なぜ起こるのか
Bupropion inhibits CYP2D6, reducing clearance of deutetrabenazine's active dihydro-metabolites.
対処法
Limit deutetrabenazine to no more than 18 mg per dose and 36 mg per day while bupropion is used. Monitor for adverse effects such as depression, somnolence and QT prolongation.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BupropionとDeutetrabenazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Bupropionのその他の相互作用
Deutetrabenazineのその他の相互作用
よくある質問
Can I take Bupropion with Deutetrabenazine?
MediHelp rates the interaction as major. Bupropion and Deutetrabenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bupropion is a strong CYP2D6 inhibitor and markedly raises exposure to the active metabolites of deutetrabenazine. This increases the risk of sedation, akathisia, parkinsonism, depression and QT prolongation.
How serious is the interaction between Bupropion and Deutetrabenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit deutetrabenazine to no more than 18 mg per dose and 36 mg per day while bupropion is used. Monitor for adverse effects such as depression, somnolence and QT prolongation.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
