相互作用
Deutetrabenazine + Valbenazine
重症度: 併用禁忌
Deutetrabenazine and Valbenazine: contraindicated interaction.
最終更新日
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概要
Both drugs are VMAT2 inhibitors, so combining them provides duplicate therapy and increases the risk of adverse effects such as sedation, depression, parkinsonism and QT prolongation. There is no rationale for using the two together.
この相互作用をわかりやすく説明すると
Deutetrabenazine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
なぜ起こるのか
Duplicate VMAT2 inhibition causes additive pharmacodynamic effects and excessive monoamine depletion.
対処法
Do not use together; choose one VMAT2 inhibitor. Allow adequate washout when switching between agents.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、DeutetrabenazineとValbenazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Deutetrabenazineのその他の相互作用
Valbenazineのその他の相互作用
よくある質問
Can I take Deutetrabenazine with Valbenazine?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Valbenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are VMAT2 inhibitors, so combining them provides duplicate therapy and increases the risk of adverse effects such as sedation, depression, parkinsonism and QT prolongation. There is no rationale for using the two together.
How serious is the interaction between Deutetrabenazine and Valbenazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose one VMAT2 inhibitor. Allow adequate washout when switching between agents.
What other medicines interact with Deutetrabenazine?
MediHelp also lists interactions of Deutetrabenazine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Deutetrabenazine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
