医薬品リファレンス
Atidarsagene autotemcel
Atidarsagene autotemcel is a medicine in the class miscellaneous.
- 薬効分類: Miscellaneous
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Miscellaneous
- 既知の相互作用
- 14 (重大: 11 · 中等度: 3)
- 商品名
- 1
- 国・市場
- 1
作用のしくみ
Autologous CD34+ cells are transduced with an ARSA lentiviral vector, inserting functional ARSA cDNA copies into HSCs. After infusion the cells engraft, repopulate the hematopoietic compartment and produce ARSA enzyme, which can break down or prevent harmful sulfatide accumulation.
妊娠と授乳
- 妊娠
- Unsafe No clinical data. Must not be given during pregnancy because of risks of the required myeloablative conditioning. Confirm a negative pregnancy test before treatment.
- 授乳
- Unsafe No data on milk. Breastfeeding should be stopped during conditioning; follow the conditioning agent's guidance.
報告されている副作用
- Febrile neutropenia
- Stomatitis
- Respiratory tract infections
- Rash
- Device related infections
- Other viral infections
注意が必要な方
- Thrombosis and thromboembolic events: a fatal cerebral infarction occurred; evaluate thrombosis risk factors before and after infusion and consider anti-thrombotic prophylaxis.
- Encephalitis: monitor for signs or symptoms after treatment; may trigger relapsing-remitting disease progression.
- Serious infection: severe Grade 3 infections occurred in 39% of children; monitor and give prophylactic antimicrobials.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (14)
- Atidarsagene autotemcel + Didanosine Major
- Atidarsagene autotemcel + Dolutegravir Major
- Atidarsagene autotemcel + Efavirenz Major
- Atidarsagene autotemcel + Emtricitabine Major
- Atidarsagene autotemcel + Lamivudine Major
- Atidarsagene autotemcel + Measles mumps and rubella vaccine Major
- Atidarsagene autotemcel + Nevirapine Major
- Atidarsagene autotemcel + Raltegravir Major
- Atidarsagene autotemcel + Stavudine Major
- Atidarsagene autotemcel + Tenofovir disoproxil Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Atidarsagene autotemcelの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Patient counselling points
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Atidarsagene autotemcel used for?
Atidarsagene autotemcel is a medicine in the class miscellaneous.
What side effects have been reported with Atidarsagene autotemcel?
Febrile neutropenia, Stomatitis, Respiratory tract infections, Rash, Device related infections, Other viral infections.
Can Atidarsagene autotemcel be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No clinical data. Must not be given during pregnancy because of risks of the required myeloablative conditioning. Confirm a negative pregnancy test before treatment. Breastfeeding: Unsafe. No data on milk. Breastfeeding should be stopped during conditioning; follow the conditioning agent's guidance.
What does Atidarsagene autotemcel interact with?
MediHelp lists 14 known interactions for Atidarsagene autotemcel. Major: 11 · Moderate: 3. The most serious include Didanosine, Dolutegravir, Efavirenz.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
