医薬品リファレンス
Galcanezumab
Galcanezumab is a medicine in the class central nervous system. It is used for cluster headache.
- 薬効分類: Central Nervous System
- 効能・効果: cluster headache
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Central Nervous System
- 一般的な剤形
- 注射剤
- 一般的な規格
- 120 mg/ml, 100 mg/ml
- 既知の相互作用
- 3 (中等度: 3)
- 商品名
- 5
- 国・市場
- 5
何に使われるか
作用のしくみ
Humanized monoclonal antibody; binds to calcitonin gene-related peptide (CGRP) ligand and blocks its binding to the receptor
成人の通常用量（添付文書の要約）
Migraine Prophylaxis: Loading dose: 240 mg SC once (ie, 2 consecutive 120-mg SC injections), Maintenance dose: 120 mg SC monthly
妊娠と授乳
- 妊娠
- Unknown No adequate human data; no harm in rat and rabbit studies. As an IgG antibody it crosses the placenta, mainly late in pregnancy, and exposure continues for months after the last dose; a pregnancy registry exists. EU label: as a precaution, preferable to avoid in pregnancy.
- 授乳
- Unknown No milk data. EU label: a risk cannot be excluded in the first days after birth; afterwards use only if clinically needed. LactMed: likely very low in milk and partly digested by the infant; use with caution, especially with a newborn or preterm infant.
報告されている副作用
- Injection site reactions
- Angioedema
禁忌
- Serious hypersensitivity to galcanezumab-gnlm or to any of the excipients.
注意が必要な方
- Hypersensitivity reactions (dyspnea, urticaria, rash; anaphylaxis and angioedema postmarketing) can occur, even days after administration, and may be prolonged. If a serious reaction occurs, discontinue and treat appropriately.
- Constipation with serious complications, including hospitalization and surgery, has been reported, usually after the first dose. Monitor for severe constipation; medications that reduce GI motility may increase the risk.
- New-onset or worsening hypertension has been reported, most often within 7 days of starting. Monitor blood pressure and consider discontinuation if no other cause is found or BP is inadequately controlled.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (3)
- Efgartigimod / hyaluronidase sc + Galcanezumab Moderate
- Efgartigimod alfa + Galcanezumab Moderate
- Galcanezumab + Rozanolixizumab Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Galcanezumabの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Galcanezumab used for?
Galcanezumab is a medicine in the class central nervous system. It is used for Cluster headache, Migraine.
What side effects have been reported with Galcanezumab?
Injection site reactions, Angioedema.
Can Galcanezumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data; no harm in rat and rabbit studies. As an IgG antibody it crosses the placenta, mainly late in pregnancy, and exposure continues for months after the last dose; a pregnancy registry exists. EU label: as a precaution, preferable to avoid in pregnancy. Breastfeeding: Unknown. No milk data. EU label: a risk cannot be excluded in the first days after birth; afterwards use only if clinically needed. LactMed: likely very low in milk and partly digested by the infant; use with caution, especially with a newborn or preterm infant.
What does Galcanezumab interact with?
MediHelp lists 3 known interactions for Galcanezumab. Moderate: 3. The most serious include Efgartigimod / hyaluronidase sc, Efgartigimod alfa, Rozanolixizumab.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
