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医薬品リファレンス

Lopinavir

Lopinavir is a medicine in the class anti virals. It is used for hiv.

最終更新日 出典: US FDA label

医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。

このページの臨床コンテンツは英語でのみ提供されています。

要点

薬効分類
Anti Virals
既知の相互作用
274 (併用禁忌: 16 · 重大: 115 · 中等度: 128 · 軽度: 15)

何に使われるか

作用のしくみ

HIV-1 protease inhibitor; antiviral activity of the lopinavir/ritonavir combination is due to lopinavir, while ritonavir inhibits CYP3A metabolism of lopinavir and raises its plasma levels.

成人の通常用量（添付文書の要約）

HIV-1 infection: tablets 400/100 mg (two 200/50 mg tablets) twice daily, or oral solution 400/100 mg (5 mL) twice daily, with other antiretrovirals

添付文書の最初の用法・用量の行のみの要約です。用法・用量の全項目はアプリでご覧いただけます。

妊娠と授乳

妊娠
Safe Antiretroviral pregnancy registry data show no rise in birth defects. In pregnancy give 400/100 mg twice daily (once-daily dosing is not recommended) and avoid the oral solution, which contains about 42% alcohol and propylene glycol. Can be part of HIV treatment.
授乳
Safe Low levels pass into milk and reach some infants' blood; no infant harm clearly caused. US label: do not breastfeed (HIV transmission, resistance). Current US guidance supports breastfeeding only with sustained viral suppression after counselling; otherwise avoid.

報告されている副作用

  • Diarrhea
  • Nausea
  • Vomiting
  • Abdominal pain
  • Headache
  • Asthenia

禁忌

  • Hypersensitivity to any ingredient, including ritonavir (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme).
  • Co-administration with drugs highly dependent on CYP3A for clearance where elevated levels cause serious or life-threatening reactions.
  • Co-administration with potent CYP3A inducers (loss of virologic response); Table 3 lists alfuzosin, rifampin, ergot derivatives, cisapride, St. John's Wort, lovastatin, simvastatin, sildenafil (Revatio), pimozide, triazolam, oral midazolam.

注意が必要な方

  • CYP3A inhibition can raise levels of concomitant drugs, causing severe or fatal events; review all medications.
  • Pancreatitis, including fatalities; suspend therapy as clinically appropriate if suspected.
  • Hepatotoxicity: monitor liver function, especially with underlying hepatitis B or C or cirrhosis.

妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。

主な相互作用 (274)

All 274 interactions, with severity and what to do

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アカウントを作成してPro+トライアルを始めると、Lopinavirの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。

  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Paediatric dosing
  • Dosing in older adults
  • How to give it
  • Pharmacokinetics
  • Patient counselling points
  • Food interactions
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同じ分類のほかの薬剤

よくある質問

What is Lopinavir used for?

Lopinavir is a medicine in the class anti virals. It is used for HIV.

What side effects have been reported with Lopinavir?

Diarrhea, Nausea, Vomiting, Abdominal pain, Headache, Asthenia.

Can Lopinavir be taken in pregnancy or while breastfeeding?

Pregnancy: Safe. Antiretroviral pregnancy registry data show no rise in birth defects. In pregnancy give 400/100 mg twice daily (once-daily dosing is not recommended) and avoid the oral solution, which contains about 42% alcohol and propylene glycol. Can be part of HIV treatment. Breastfeeding: Safe. Low levels pass into milk and reach some infants' blood; no infant harm clearly caused. US label: do not breastfeed (HIV transmission, resistance). Current US guidance supports breastfeeding only with sustained viral suppression after counselling; otherwise avoid.

What does Lopinavir interact with?

MediHelp lists 274 known interactions for Lopinavir. Contraindicated: 16 · Major: 115 · Moderate: 128 · Minor: 15. The most serious include Alfuzosin, Avanafil, Cisapride.

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