相互作用
Cisapride + Lopinavir
重症度: 併用禁忌
Cisapride and Lopinavir: contraindicated interaction.
最終更新日
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概要
Lopinavir boosted with ritonavir strongly inhibits CYP3A4, which is the main pathway clearing cisapride. Raised cisapride levels can cause serious QT prolongation and torsades de pointes.
この相互作用をわかりやすく説明すると
Cisapride and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cisapride belongs to Gastrointestinal Tract; Lopinavir belongs to Anti Virals.
なぜ起こるのか
Inhibition of CYP3A4-mediated cisapride metabolism by the ritonavir component, with lopinavir's own QT effect.
対処法
Do not coadminister; use an alternative prokinetic in patients on lopinavir/ritonavir.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CisaprideとLopinavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cisaprideのその他の相互作用
Lopinavirのその他の相互作用
よくある質問
Can I take Cisapride with Lopinavir?
MediHelp rates the interaction as contraindicated. Cisapride and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lopinavir boosted with ritonavir strongly inhibits CYP3A4, which is the main pathway clearing cisapride. Raised cisapride levels can cause serious QT prolongation and torsades de pointes.
How serious is the interaction between Cisapride and Lopinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative prokinetic in patients on lopinavir/ritonavir.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
