相互作用
Fluticasone-salmeterol + Lopinavir
重症度: 併用禁忌
Fluticasone-salmeterol and Lopinavir: contraindicated interaction.
最終更新日
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概要
Lopinavir/ritonavir strongly inhibits CYP3A4 and can greatly increase salmeterol exposure, with risk of QT prolongation and arrhythmias. Systemic fluticasone exposure also rises, which can lead to Cushing's syndrome and adrenal suppression.
この相互作用をわかりやすく説明すると
Fluticasone-salmeterol and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluticasone-salmeterol belongs to Respiratory; Lopinavir belongs to Anti Virals.
なぜ起こるのか
Strong CYP3A4 inhibition reduces clearance of salmeterol and fluticasone.
対処法
Avoid the combination and switch to an alternative such as beclomethasone with a different LABA. If unavoidable, monitor ECG, potassium and adrenal function.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、Fluticasone-salmeterolとLopinavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Fluticasone-salmeterolのその他の相互作用
Lopinavirのその他の相互作用
よくある質問
Can I take Fluticasone-salmeterol with Lopinavir?
MediHelp rates the interaction as contraindicated. Fluticasone-salmeterol and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lopinavir/ritonavir strongly inhibits CYP3A4 and can greatly increase salmeterol exposure, with risk of QT prolongation and arrhythmias. Systemic fluticasone exposure also rises, which can lead to Cushing's syndrome and adrenal suppression.
How serious is the interaction between Fluticasone-salmeterol and Lopinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and switch to an alternative such as beclomethasone with a different LABA. If unavoidable, monitor ECG, potassium and adrenal function.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
