相互作用
Eplerenone + Lopinavir
重症度: 併用禁忌
Eplerenone and Lopinavir: contraindicated interaction.
最終更新日
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概要
Lopinavir is co-formulated with ritonavir, which strongly inhibits CYP3A4 and increases eplerenone exposure. This raises the risk of serious hyperkalemia.
この相互作用をわかりやすく説明すると
Eplerenone and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eplerenone belongs to Cardiovascular; Lopinavir belongs to Anti Virals.
なぜ起こるのか
Ritonavir-boosted lopinavir strongly inhibits CYP3A4-mediated metabolism of eplerenone.
対処法
Avoid the combination; use an alternative mineralocorticoid antagonist strategy or a different antiretroviral, and monitor potassium if exposure occurs.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、EplerenoneとLopinavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Eplerenoneのその他の相互作用
Lopinavirのその他の相互作用
よくある質問
Can I take Eplerenone with Lopinavir?
MediHelp rates the interaction as contraindicated. Eplerenone and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lopinavir is co-formulated with ritonavir, which strongly inhibits CYP3A4 and increases eplerenone exposure. This raises the risk of serious hyperkalemia.
How serious is the interaction between Eplerenone and Lopinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative mineralocorticoid antagonist strategy or a different antiretroviral, and monitor potassium if exposure occurs.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
