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Nelarabine

Nelarabine is a medicine in the class oncology. It is used for acute lymphocytic leukemia.

最終更新日 出典: US FDA label

医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。

このページの臨床コンテンツは英語でのみ提供されています。

要点

薬効分類
Oncology
ATCコード
L01BB07
一般的な剤形
注射剤
一般的な規格
5 mg/ml
既知の相互作用
9 (重大: 4 · 中等度: 4 · 軽度: 1)
商品名
2
国・市場
2

剤形、規格、商品名は国によって異なります。お手元の製品をご確認ください。

何に使われるか

作用のしくみ

Nelarabine is a prodrug of ara-G, a nucleoside metabolic inhibitor. It is demethylated by ADA to ara-G and converted to the active triphosphate ara-GTP, which is incorporated into DNA, inhibiting DNA synthesis and causing cell death.

成人の通常用量（添付文書の要約）

Relapsed or refractory T-ALL/T-LBL: 1,500 mg/m2 by intravenous infusion over 2 hours on Days 1, 3, and 5, repeated every 21 days; administer undiluted

添付文書の最初の用法・用量の行のみの要約です。用法・用量の全項目はアプリでご覧いただけます。

妊娠と授乳

妊娠
Unsafe Can cause fetal harm: it was teratogenic in rabbits at doses below the human dose; human data are too limited. Check pregnancy status before starting; women should use effective contraception during treatment and men should use condoms during and for 3 months after.
授乳
Unsafe No data on milk levels. e-lactancia: incompatible; a small, poorly protein-bound molecule likely to pass into milk. US label: do not breastfeed during treatment because of possible serious infant reactions, such as severe nerve toxicity.

報告されている副作用

  • Anemia
  • Thrombocytopenia
  • Neutropenia
  • Fatigue
  • Nausea
  • Cough

警告（枠囲み警告）

  • Severe neurologic adverse reactions have occurred, including altered mental states with severe somnolence, convulsions, peripheral neuropathy from numbness and paresthesias to weakness and paralysis, demyelination, and ascending neuropathy similar to Guillain-Barré syndrome. Full recovery has not always occurred after stopping therapy. Monitor frequently for neurologic toxicity and discontinue for CTCAE Grade 2 or greater neurologic reactions.

注意が必要な方

  • Neurologic toxicity: monitor during and for at least 24 hours after treatment. Prior or concurrent intrathecal chemotherapy or prior craniospinal irradiation may increase risk.
  • Hematologic toxicity: leukopenia, thrombocytopenia, anemia and neutropenia; monitor complete blood counts including platelets regularly.
  • Embryo-fetal toxicity: can cause fetal harm; verify pregnancy status, use effective contraception, and males should use condoms during treatment and for 3 months after the last dose.

妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。

主な相互作用 (9)

Pro+会員向け

ページ全体を見る

アカウントを作成してPro+トライアルを始めると、Nelarabineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。

  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Paediatric dosing
  • Dosing in older adults
  • How to give it
  • Pharmacokinetics
  • Patient counselling points
  • IV preparation and dilution
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同じ分類のほかの薬剤

よくある質問

What is Nelarabine used for?

Nelarabine is a medicine in the class oncology. It is used for Acute lymphocytic leukemia, Lymphoma.

What side effects have been reported with Nelarabine?

Anemia, Thrombocytopenia, Neutropenia, Fatigue, Nausea, Cough. Serious warning: Severe neurologic adverse reactions have occurred, including altered mental states with severe somnolence, convulsions, peripheral neuropathy from numbness and paresthesias to weakness and paralysis, demyelination, and ascending neuropathy similar to Guillain-Barré syndrome.

Can Nelarabine be taken in pregnancy or while breastfeeding?

Pregnancy: Unsafe. Can cause fetal harm: it was teratogenic in rabbits at doses below the human dose; human data are too limited. Check pregnancy status before starting; women should use effective contraception during treatment and men should use condoms during and for 3 months after. Breastfeeding: Unsafe. No data on milk levels. e-lactancia: incompatible; a small, poorly protein-bound molecule likely to pass into milk. US label: do not breastfeed during treatment because of possible serious infant reactions, such as severe nerve toxicity.

What does Nelarabine interact with?

MediHelp lists 9 known interactions for Nelarabine. Major: 4 · Moderate: 4 · Minor: 1. The most serious include Deferiprone, Pentostatin, Siponimod.

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