医薬品リファレンス
Nelfinavir
Nelfinavir is a medicine in the class anti virals. It is used for hiv.
- 薬効分類: Anti Virals
- 効能・効果: hiv
最終更新日 出典: US FDA label
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要点
- 薬効分類
- Anti Virals
- 一般的な剤形
- 錠剤
- 既知の相互作用
- 286 (併用禁忌: 16 · 重大: 80 · 中等度: 150 · 軽度: 40)
- 商品名
- 1
- 国・市場
- 1
何に使われるか
作用のしくみ
Nelfinavir is an inhibitor of the HIV-1 protease.
成人の通常用量（添付文書の要約）
HIV-1 infection, adults and adolescents 13 years and older (tablets): 1250 mg twice daily or 750 mg three times daily, oral, with a meal, in combination with other antiretrovirals
妊娠と授乳
- 妊娠
- Unknown Consider alternative antiretrovirals during pregnancy because of hepatic adverse events and decreased exposure in 2nd/3rd trimesters; APR data show a birth defect rate of 3.9% with first trimester exposure. Clinical monitoring is recommended if used.
- 授乳
- Unsafe Nelfinavir is present in low levels in human milk; mothers are instructed not to breastfeed because of HIV transmission and infant adverse reaction risks.
報告されている副作用
- Diarrhea
- Nausea
- Rash
- Flatulence
- Leukopenia/neutropenia (pediatric)
- Anorexia (pediatric)
禁忌
- Coadministration with drugs highly dependent on CYP3A for clearance whose elevated concentrations cause serious or life-threatening events (e.g. alfuzosin, amiodarone, quinidine, lurasidone, pimozide, ergot derivatives, cisapride, lovastatin, simvastatin, sildenafil for PAH, triazolam, oral midazol…
- Rifampin and St. John's wort are contraindicated because they reduce nelfinavir concentrations, risking loss of effect and resistance.
注意が必要な方
- Drug interactions via CYP3A may cause serious adverse reactions or loss of efficacy; review concomitant medications.
- Should not be used in moderate or severe hepatic impairment.
- Oral powder contains phenylalanine (11.2 mg per gram), harmful in phenylketonuria.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (286)
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
- Ivabradine + Nelfinavir Contraindicated
- Lovastatin + Nelfinavir Contraindicated
- Lurasidone + Nelfinavir Contraindicated
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Nelfinavirの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
関連するクイックリード
よくある質問
What is Nelfinavir used for?
Nelfinavir is a medicine in the class anti virals. It is used for HIV.
What side effects have been reported with Nelfinavir?
Diarrhea, Nausea, Rash, Flatulence, Leukopenia/neutropenia (pediatric), Anorexia (pediatric).
Can Nelfinavir be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Consider alternative antiretrovirals during pregnancy because of hepatic adverse events and decreased exposure in 2nd/3rd trimesters; APR data show a birth defect rate of 3.9% with first trimester exposure. Clinical monitoring is recommended if used. Breastfeeding: Unsafe. Nelfinavir is present in low levels in human milk; mothers are instructed not to breastfeed because of HIV transmission and infant adverse reaction risks.
What does Nelfinavir interact with?
MediHelp lists 286 known interactions for Nelfinavir. Contraindicated: 16 · Major: 80 · Moderate: 150 · Minor: 40. The most serious include Alfuzosin, Avanafil, Dronedarone.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
