相互作用
Lovastatin + Nelfinavir
重症度: 併用禁忌
Lovastatin and Nelfinavir: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Nelfinavir inhibits CYP3A4 and increases lovastatin exposure, raising the risk of myopathy and rhabdomyolysis. The combination is contraindicated.
この相互作用をわかりやすく説明すると
Lovastatin and Nelfinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lovastatin belongs to Cardiovascular; Nelfinavir belongs to Anti Virals.
なぜ起こるのか
Inhibition of CYP3A4 metabolism of lovastatin by nelfinavir.
対処法
Do not coadminister; switch to pravastatin or rosuvastatin while on nelfinavir. Educate the patient to report muscle toxicity.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LovastatinとNelfinavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Lovastatinのその他の相互作用
Nelfinavirのその他の相互作用
よくある質問
Can I take Lovastatin with Nelfinavir?
MediHelp rates the interaction as contraindicated. Lovastatin and Nelfinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nelfinavir inhibits CYP3A4 and increases lovastatin exposure, raising the risk of myopathy and rhabdomyolysis. The combination is contraindicated.
How serious is the interaction between Lovastatin and Nelfinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; switch to pravastatin or rosuvastatin while on nelfinavir. Educate the patient to report muscle toxicity.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
