医薬品リファレンス
Olsalazine
Olsalazine is a medicine in the class gastrointestinal tract. It is used for ulcerative colitis.
- 薬効分類: Gastrointestinal Tract
- 効能・効果: ulcerative colitis
最終更新日
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要点
- 薬効分類
- Gastrointestinal Tract
- 一般的な剤形
- カプセル剤
- 一般的な規格
- 250 mg
- 既知の相互作用
- 1 (軽度: 1)
- 商品名
- 3
- 国・市場
- 3
何に使われるか
作用のしくみ
Converted to 5-aminosalicylic acid (mesalamine) by gastrointestinal flora which is thought to be the therapeutically active component; works topically rather than systemically.
成人の通常用量（添付文書の要約）
Ulcerative Colitis Maintenance: 1g PO qDay in 2 divided doses, Take with food.
妊娠と授乳
- 妊娠
- Safe It releases mesalamine (5-ASA); meta-analyses and cohort studies of mesalamine show no reliable link with birth defects or miscarriage. Rats had developmental effects at 5 to 20 times the human dose. Active ulcerative colitis itself raises pregnancy risks, so continue when needed.
- 授乳
- Safe Little olsalazine passes into milk, but mesalamine metabolites do (mesalamine relative infant dose 0.1% or less). A few infants had diarrhoea. LactMed: not a reason to stop breastfeeding; watch the infant for diarrhoea. US label: weigh benefits.
報告されている副作用
- Headache
- Diarrhea
- Abdominal pain
- Nausea/vomiting
禁忌
- Patients with known or suspected hypersensitivity to salicylates, aminosalicylates or their metabolites, or excipients
注意が必要な方
- Patients with pre-existing skin conditions such as atopic dermatitis and atopic eczema have reported more severe photosensitivity reactions when receiving therapy.
- Cases of nephrolithiasis have been reported with use of mesalamine; active moiety in drug, including stones with 100% mesalamine content.
- advise patients to avoid sun exposure, wear protective clothing, and use a broad-spectrum sunscreen when outdoors
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (1)
- Olsalazine + Warfarin Minor
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Olsalazineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Olsalazine used for?
Olsalazine is a medicine in the class gastrointestinal tract. It is used for Ulcerative colitis.
What side effects have been reported with Olsalazine?
Headache, Diarrhea, Abdominal pain, Nausea/vomiting.
Can Olsalazine be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. It releases mesalamine (5-ASA); meta-analyses and cohort studies of mesalamine show no reliable link with birth defects or miscarriage. Rats had developmental effects at 5 to 20 times the human dose. Active ulcerative colitis itself raises pregnancy risks, so continue when needed. Breastfeeding: Safe. Little olsalazine passes into milk, but mesalamine metabolites do (mesalamine relative infant dose 0.1% or less). A few infants had diarrhoea. LactMed: not a reason to stop breastfeeding; watch the infant for diarrhoea. US label: weigh benefits.
What does Olsalazine interact with?
MediHelp lists 1 known interactions for Olsalazine. Minor: 1. The most serious include Warfarin.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
