医薬品リファレンス
Mesalamine
Mesalamine is a medicine in the class gastrointestinal tract. It is used for ulcerative colitis.
- 薬効分類: Gastrointestinal Tract
- 効能・効果: ulcerative colitis
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Gastrointestinal Tract
- 別名
- Mesalazine
- 一般的な剤形
- 錠剤, カプセル剤, 坐剤, 分包, 経口懸濁液
- 一般的な規格
- 1 g, 500 mg, 2 g
- 既知の相互作用
- 125 (重大: 2 · 中等度: 48 · 軽度: 75)
- 商品名
- 50
- 国・市場
- 5
何に使われるか
作用のしくみ
Anti-inflammatory agent; mesalamine (5-aminosalicylic acid) is the active component of sulfasalazine, but specific MOA is unknown; probably inhibits prostaglandin and leukotriene synthesis and release in colon.
成人の通常用量（添付文書の要約）
Ulcerative Colitis (Pentasa): 1 g/day orally four times daily for up to 8 weeks.
妊娠と授乳
- 妊娠
- Safe Meta-analyses and cohort studies show no reliable link with birth defects, miscarriage or poor outcomes; no harm in animals. Active ulcerative colitis itself raises pregnancy risks, so continue treatment.
- 授乳
- Safe Passes into milk in small amounts (mesalamine 0.1% or less of the maternal dose; more of an inactive metabolite). A few infants had diarrhoea. LactMed: not a reason to stop breastfeeding; watch the infant for diarrhoea.
報告されている副作用
- Headache
- Abdominal pain
- Flatulence
- GI discomfort
禁忌
- Hypersensitivity to mesalamine or salicylates
- Breastfeeding
- Rectal suspension: Hypersensitivity to salicylates, aminosalicylates or to any ingredients in the suppository vehicle
注意が必要な方
- Oligospermia has been reported in males.
- ensure adequate fluid intake during treatment; evaluate renal function prior to initiation of therapy and periodically while on therapy.
- advise patients to avoid sun exposure, wear protective clothing, and use a broad-spectrum sunscreen when outdoors.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (125)
- Measles mumps rubella and varicella vaccine live + Mesalamine Major
- Mesalamine + Varicella virus vaccine live Major
- Aceclofenac + Mesalamine Moderate
- Acemetacin + Mesalamine Moderate
- Acetylsalicylic acid + Mesalamine Moderate
- Aspirin + Mesalamine Moderate
- Aspirin / citric acid / sodium bicarbonate + Mesalamine Moderate
- Aspirin rectal + Mesalamine Moderate
- Azathioprine + Mesalamine Moderate
- Balsalazide + Mesalamine Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Mesalamineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Mesalamine used for?
Mesalamine is a medicine in the class gastrointestinal tract. It is used for Ulcerative colitis.
What side effects have been reported with Mesalamine?
Headache, Abdominal pain, Flatulence, GI discomfort.
Can Mesalamine be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Meta-analyses and cohort studies show no reliable link with birth defects, miscarriage or poor outcomes; no harm in animals. Active ulcerative colitis itself raises pregnancy risks, so continue treatment. Breastfeeding: Safe. Passes into milk in small amounts (mesalamine 0.1% or less of the maternal dose; more of an inactive metabolite). A few infants had diarrhoea. LactMed: not a reason to stop breastfeeding; watch the infant for diarrhoea.
What does Mesalamine interact with?
MediHelp lists 125 known interactions for Mesalamine. Major: 2 · Moderate: 48 · Minor: 75. The most serious include Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
