医薬品リファレンス
Tobramycin
Tobramycin is a medicine in the class anti bacterial. It is used for bacterial infections.
- 薬効分類: Anti Bacterial
- 効能・効果: bacterial infections
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Anti Bacterial
- ATCコード
- J01GB01
- 一般的な剤形
- 点滴剤, 軟膏剤, 溶液, 注射剤, カプセル剤
- 一般的な規格
- 0.3%, 20 mg/2 ml, 28 mg
- 既知の相互作用
- 141 (併用禁忌: 1 · 重大: 41 · 中等度: 75 · 軽度: 24)
- 商品名
- 41
- 国・市場
- 5
何に使われるか
作用のしくみ
Inhibits protein synthesis by irreversibly binding to bacterial 30S and 50S ribosomes
成人の通常用量（添付文書の要約）
Bacterial Infections: 3-6 mg/kg/day IV/IM divided q8hr OR 4-7 mg/kg/dose IV/IM qDay
妊娠と授乳
- 妊娠
- Unsafe Injection: aminoglycosides can cause fetal harm; streptomycin has caused permanent congenital deafness. Use only for serious infections with drug-level monitoring. Inhaled form gives minimal absorption. Eye/ear drops: little absorbed; acceptable.
- 授乳
- Safe Poorly excreted into milk; infant blood levels are far below treatment levels. LactMed: acceptable; watch for diarrhoea, thrush or nappy rash. Inhaled tobramycin is compatible (respiratory experts); eye or ear drops pose little or no risk.
報告されている副作用
- Neurotoxicity
- Increased lacrimation
- Nephrotoxicity
- Itching and edema of eyelid
- Ototoxicity
禁忌
- Documented hypersensitivity to any aminoglycoside or history of hypersensitivity or serious toxic reactions to aminoglycosides
注意が必要な方
- Monitor serum aminoglycoside concentrations if concurrent systemic aminoglycoside therapy is in progress
- May result in overgrowth of nonsusceptible organisms, including fungi
- Cross-allergenicity among aminoglycosides has been demonstrated
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (141)
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Atracurium + Tobramycin Major
- Bacitracin + Tobramycin Major
- Bumetanide + Tobramycin Major
- Capreomycin + Tobramycin Major
- Cephaloridine + Tobramycin Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Tobramycinの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Tobramycin used for?
Tobramycin is a medicine in the class anti bacterial. It is used for Bacterial infections, Conjunctivitis, Cystic fibrosis.
What side effects have been reported with Tobramycin?
Neurotoxicity, Increased lacrimation, Nephrotoxicity, Itching and edema of eyelid, Ototoxicity.
Can Tobramycin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Injection: aminoglycosides can cause fetal harm; streptomycin has caused permanent congenital deafness. Use only for serious infections with drug-level monitoring. Inhaled form gives minimal absorption. Eye/ear drops: little absorbed; acceptable. Breastfeeding: Safe. Poorly excreted into milk; infant blood levels are far below treatment levels. LactMed: acceptable; watch for diarrhoea, thrush or nappy rash. Inhaled tobramycin is compatible (respiratory experts); eye or ear drops pose little or no risk.
What does Tobramycin interact with?
MediHelp lists 141 known interactions for Tobramycin. Contraindicated: 1 · Major: 41 · Moderate: 75 · Minor: 24. The most serious include Cidofovir, Adefovir, Amikacin.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
