相互作用
Cephaloridine + Tobramycin
重症度: 重大
Cephaloridine and Tobramycin: major interaction.
最終更新日
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概要
Cephaloridine is itself markedly nephrotoxic and was withdrawn from use for that reason. Combined with tobramycin, the risk of tubular necrosis and kidney failure is substantially increased, and ototoxicity from the aminoglycoside may become more likely as renal clearance falls.
この相互作用をわかりやすく説明すると
Cephaloridine and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive proximal tubular toxicity, with reduced renal clearance of tobramycin raising its exposure.
対処法
Avoid the combination; cephaloridine is obsolete and a safer cephalosporin should be chosen. If it cannot be avoided, monitor creatinine and tobramycin levels closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CephaloridineとTobramycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tobramycinのその他の相互作用
よくある質問
Can I take Cephaloridine with Tobramycin?
MediHelp rates the interaction as major. Cephaloridine and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cephaloridine is itself markedly nephrotoxic and was withdrawn from use for that reason. Combined with tobramycin, the risk of tubular necrosis and kidney failure is substantially increased, and ototoxicity from the aminoglycoside may become more likely as renal clearance falls.
How serious is the interaction between Cephaloridine and Tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; cephaloridine is obsolete and a safer cephalosporin should be chosen. If it cannot be avoided, monitor creatinine and tobramycin levels closely.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
