相互作用
Amikacin + Tobramycin
重症度: 重大
Amikacin and Tobramycin: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Combining two systemic aminoglycosides gives no therapeutic advantage and substantially increases the risk of nephrotoxicity, ototoxicity and neuromuscular blockade. Toxicity may be irreversible, particularly hearing and vestibular damage.
この相互作用をわかりやすく説明すると
Amikacin and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amikacin belongs to Anti Bacterial; Tobramycin belongs to Anti Bacterial.
なぜ起こるのか
Additive aminoglycoside accumulation in renal proximal tubular cells and inner ear hair cells.
対処法
Avoid concurrent systemic use of two aminoglycosides and select a single agent with therapeutic drug monitoring. Monitor renal function and audiovestibular symptoms if overlap is unavoidable.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmikacinとTobramycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Amikacinのその他の相互作用
Tobramycinのその他の相互作用
よくある質問
Can I take Amikacin with Tobramycin?
MediHelp rates the interaction as major. Amikacin and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two systemic aminoglycosides gives no therapeutic advantage and substantially increases the risk of nephrotoxicity, ototoxicity and neuromuscular blockade. Toxicity may be irreversible, particularly hearing and vestibular damage.
How serious is the interaction between Amikacin and Tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent systemic use of two aminoglycosides and select a single agent with therapeutic drug monitoring. Monitor renal function and audiovestibular symptoms if overlap is unavoidable.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
