医薬品リファレンス
Tranexamic acid
Tranexamic acid is a medicine in the class cardiovascular. It is used for hemorrhage.
- 薬効分類: Cardiovascular
- 効能・効果: hemorrhage
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Cardiovascular
- 一般的な剤形
- 注射剤, 錠剤
- 一般的な規格
- 500 mg, 500 mg/5 ml, 100 mg/ml
- 既知の相互作用
- 16 (併用禁忌: 6 · 重大: 7 · 中等度: 3)
- 商品名
- 37
- 国・市場
- 4
何に使われるか
作用のしくみ
Antifibrinolytic; synthetic lysine amino acid derivative, which diminishes the dissolution of hemostatic fibrin by plasmin In the presence of tranexamic acid, the lysine receptor binding sites of plasmin for fibrin are occupied, preventing binding to fibrin monomers, thus preserving and stabilizing fibrin’s matrix structure
成人の通常用量（添付文書の要約）
Menorrhagia: 1300 mg PO TID for up to 5 days during menstruation
妊娠と授乳
- 妊娠
- Safe Crosses the placenta. Use in the 2nd and 3rd trimesters and at delivery has not shown clear harm, and it is widely used for bleeding after birth (WHO). Rare fatal fetal abnormalities after 1st-trimester use, with confounders. No harm in animals. Use when needed for bleeding, not for heavy periods.
- 授乳
- Safe Passes into milk in low amounts. US/UK labels: no final assessment; weigh benefits. LactMed: expert opinion considers that breastfeeding should be permitted when the mother needs tranexamic acid.
報告されている副作用
- Headache
- Nausea
- Back pain
- Nasal and sinus symptoms
- Visual abnormalities
注意が必要な方
- May cause cerebral edema and cerebral infarction in women with subarachnoid hemorrhage
- Severe allergic reaction reported; anaphylactic shock reported with IV product
- Concurrent use with tretinoin may exacerbate procoagulant effects
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (16)
- Dienogest / estradiol valerate + Tranexamic acid Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Ethinylestradiol + Tranexamic acid Contraindicated
- Mestranol + Tranexamic acid Contraindicated
- Alteplase + Tranexamic acid Major
- Anti-inhibitor coagulant complex + Tranexamic acid Major
- Factor ix + Tranexamic acid Major
- Factor ix complex + Tranexamic acid Major
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Tranexamic acidの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Tranexamic acid used for?
Tranexamic acid is a medicine in the class cardiovascular. It is used for Hemorrhage, Melasma, Menorrhagia, Uterine fibroids.
What side effects have been reported with Tranexamic acid?
Headache, Nausea, Back pain, Nasal and sinus symptoms, Visual abnormalities.
Can Tranexamic acid be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Crosses the placenta. Use in the 2nd and 3rd trimesters and at delivery has not shown clear harm, and it is widely used for bleeding after birth (WHO). Rare fatal fetal abnormalities after 1st-trimester use, with confounders. No harm in animals. Use when needed for bleeding, not for heavy periods. Breastfeeding: Safe. Passes into milk in low amounts. US/UK labels: no final assessment; weigh benefits. LactMed: expert opinion considers that breastfeeding should be permitted when the mother needs tranexamic acid.
What does Tranexamic acid interact with?
MediHelp lists 16 known interactions for Tranexamic acid. Contraindicated: 6 · Major: 7 · Moderate: 3. The most serious include Dienogest / estradiol valerate, Ethinyl estradiol-drospirenone, Ethinyl estradiol-levonorgestrel.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
