医薬品リファレンス

Valbenazine

Valbenazine is a medicine in the class central nervous system. It is used for tardive dyskinesia.

薬効分類: Central Nervous System
効能・効果: tardive dyskinesia

最終更新日 15 10月 2026 出典: US FDA label

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要点

薬効分類: Central Nervous System
一般的な剤形: カプセル剤
既知の相互作用: 135 (併用禁忌: 2 · 重大: 24 · 中等度: 105 · 軽度: 4)
商品名: 2
国・市場: 1

剤形、規格、商品名は国によって異なります。お手元の製品をご確認ください。

何に使われるか

Tardive dyskinesia

作用のしくみ

Mechanism in tardive dyskinesia and Huntington's chorea is unclear, but thought to be mediated through reversible inhibition of vesicular monoamine transporter 2 (VMAT2), which regulates monoamine uptake from the cytoplasm into synaptic vesicles.

成人の通常用量（添付文書の要約）

Tardive dyskinesia: initial 40 mg orally once daily; after one week increase to the recommended 80 mg once daily; 40 mg or 60 mg once daily may be considered depending on response and tolerability.

添付文書の最初の用法・用量の行のみの要約です。用法・用量の全項目はアプリでご覧いただけます。

妊娠と授乳

妊娠: Unsafe May cause fetal harm; human data insufficient. Animal studies showed increased stillbirths and postnatal pup mortality at doses below the MRHD. Advise pregnant women of potential fetal risk.
授乳: Unsafe No human milk data; advise women not to breastfeed during treatment and for 5 days after the final dose.

報告されている副作用

Somnolence (somnolence, fatigue, sedation)
Anticholinergic effects
Balance disorders/fall
Headache
Akathisia
Vomiting

警告（枠囲み警告）

VMAT2 inhibitors, including valbenazine, can increase the risk of depression and suicidal thoughts and behavior in patients with Huntington's disease. Balance these risks against the clinical need for chorea treatment, monitor closely for emergence or worsening of depression, suicidality or unusual behavior changes, inform patients, caregivers and families to report concerning behaviors promptly, and use particular caution in patients with a history of depression or prior suicide attempts or ideation.

禁忌

History of hypersensitivity to valbenazine or any components of the product.

注意が必要な方

Hypersensitivity reactions including angioedema (involving larynx, glottis, lips, eyelids) can occur and may be fatal; discontinue if they occur.
Somnolence and sedation: avoid driving or operating hazardous machinery until effects are known.
QT prolongation: may be clinically significant with strong CYP2D6/CYP3A4 inhibitors or in CYP2D6 poor metabolizers; avoid in congenital long QT syndrome or arrhythmias associated with prolonged QT.

妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。

主な相互作用 (135)

Deutetrabenazine + Valbenazine Contraindicated
Tranylcypromine + Valbenazine Contraindicated
Amiodarone + Valbenazine Major
Amisulpride + Valbenazine Major
Apalutamide + Valbenazine Major
Carbamazepine + Valbenazine Major
Cisapride + Valbenazine Major
Clarithromycin + Valbenazine Major
Dronedarone + Valbenazine Major
Enzalutamide + Valbenazine Major

All 135 interactions, with severity and what to do

Pro+会員向け

ページ全体を見る

アカウントを作成してPro+トライアルを始めると、Valbenazineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。

Dosing by age, kidney and liver function, and further dose lines
Renal and hepatic dose adjustments
Dosing in older adults
How to give it
Pharmacokinetics
Patient counselling points
Food interactions
IV preparation and dilution

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よくある質問

What is Valbenazine used for?

Valbenazine is a medicine in the class central nervous system. It is used for Tardive dyskinesia.

What side effects have been reported with Valbenazine?

Somnolence (somnolence, fatigue, sedation), Anticholinergic effects, Balance disorders/fall, Headache, Akathisia, Vomiting. Serious warning: VMAT2 inhibitors, including valbenazine, can increase the risk of depression and suicidal thoughts and behavior in patients with Huntington's disease.

Can Valbenazine be taken in pregnancy or while breastfeeding?

Pregnancy: Unsafe. May cause fetal harm; human data insufficient. Animal studies showed increased stillbirths and postnatal pup mortality at doses below the MRHD. Advise pregnant women of potential fetal risk. Breastfeeding: Unsafe. No human milk data; advise women not to breastfeed during treatment and for 5 days after the final dose.

What does Valbenazine interact with?

MediHelp lists 135 known interactions for Valbenazine. Contraindicated: 2 · Major: 24 · Moderate: 105 · Minor: 4. The most serious include Deutetrabenazine, Tranylcypromine, Amiodarone.

完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで

MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。

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