相互作用
Amisulpride + Valbenazine
重症度: 重大
Amisulpride and Valbenazine: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Both amisulpride and valbenazine can prolong the QT interval, so combined use may increase the risk of ventricular arrhythmias including torsades de pointes. Risk is higher with electrolyte disturbances, bradycardia, or other QT-prolonging drugs. Valbenazine is also associated with somnolence, which may be additive.
この相互作用をわかりやすく説明すると
Amisulpride and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
なぜ起こるのか
Additive prolongation of cardiac repolarization (QT interval).
対処法
Obtain a baseline ECG and monitor QTc if the combination is needed. Correct potassium and magnesium abnormalities and avoid other QT-prolonging drugs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmisulprideとValbenazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amisulprideのその他の相互作用
Valbenazineのその他の相互作用
よくある質問
Can I take Amisulpride with Valbenazine?
MediHelp rates the interaction as major. Amisulpride and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both amisulpride and valbenazine can prolong the QT interval, so combined use may increase the risk of ventricular arrhythmias including torsades de pointes. Risk is higher with electrolyte disturbances, bradycardia, or other QT-prolonging drugs. Valbenazine is also associated with somnolence, which may be additive.
How serious is the interaction between Amisulpride and Valbenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc if the combination is needed. Correct potassium and magnesium abnormalities and avoid other QT-prolonging drugs.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
