相互作用
Carbamazepine + Valbenazine
重症度: 重大
Carbamazepine and Valbenazine: major interaction.
最終更新日
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概要
Carbamazepine lowers valbenazine and its active metabolite exposure substantially. This can cause loss of efficacy in tardive dyskinesia or chorea.
この相互作用をわかりやすく説明すると
Carbamazepine and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
なぜ起こるのか
Strong CYP3A4 induction by carbamazepine increases the clearance of valbenazine and its active metabolite.
対処法
Avoid the combination as recommended in valbenazine labeling. Consider an alternative anticonvulsant if clinically feasible.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CarbamazepineとValbenazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Carbamazepineのその他の相互作用
Valbenazineのその他の相互作用
よくある質問
Can I take Carbamazepine with Valbenazine?
MediHelp rates the interaction as major. Carbamazepine and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine lowers valbenazine and its active metabolite exposure substantially. This can cause loss of efficacy in tardive dyskinesia or chorea.
How serious is the interaction between Carbamazepine and Valbenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination as recommended in valbenazine labeling. Consider an alternative anticonvulsant if clinically feasible.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
