医薬品リファレンス
Valrubicin
Valrubicin is a medicine in the class oncology. It is used for bladder cancer.
- 薬効分類: Oncology
- 効能・効果: bladder cancer
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- 一般的な剤形
- 溶液
- 一般的な規格
- 40 mg/ml
- 商品名
- 1
- 国・市場
- 1
何に使われるか
作用のしくみ
Anthracycline that inhibits incorporation of nucleosides into nucleic acids, causes chromosomal damage and arrests the cell cycle in G2. Its metabolites interfere with the DNA breaking-resealing action of DNA topoisomerase II.
成人の通常用量（添付文書の要約）
BCG-refractory carcinoma in situ of the urinary bladder: 800 mg, intravesical, once a week for six weeks; delay at least two weeks after transurethral resection and/or fulguration
妊娠と授乳
- 妊娠
- Unsafe Can cause fetal harm; no human data. In rats, IV valrubicin caused embryo-fetal malformations and increased resorptions.
- 授乳
- Unsafe No data on milk presence; advise not to breastfeed during treatment and for 2 weeks after the final dose.
報告されている副作用
- Urinary frequency
- Dysuria
- Urinary urgency
- Bladder spasm
- Hematuria
- Bladder pain
禁忌
- Perforated bladder or compromised bladder mucosa
- Known hypersensitivity to anthracyclines or polyoxyl castor oil
- Active urinary tract infection
注意が必要な方
- Delaying cystectomy can lead to metastatic bladder cancer, which is lethal; reconsider cystectomy if no complete response after 3 months or if CIS recurs.
- Evaluate the bladder before instillation; do not give to patients with perforated bladder or compromised mucosa, as systemic exposure and severe leukopenia/neutropenia can occur.
- Use with caution in severe irritable bladder symptoms; bladder spasm and spontaneous discharge of instillate may occur; clamping the catheter is not advised.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Valrubicinの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
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同じ分類のほかの薬剤
よくある質問
What is Valrubicin used for?
Valrubicin is a medicine in the class oncology. It is used for Bladder cancer.
What side effects have been reported with Valrubicin?
Urinary frequency, Dysuria, Urinary urgency, Bladder spasm, Hematuria, Bladder pain.
Can Valrubicin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm; no human data. In rats, IV valrubicin caused embryo-fetal malformations and increased resorptions. Breastfeeding: Unsafe. No data on milk presence; advise not to breastfeed during treatment and for 2 weeks after the final dose.
What does Valrubicin interact with?
MediHelp does not list a checked interaction for Valrubicin yet. Always tell your pharmacist about every medicine you take.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
