医薬品リファレンス
Topotecan
Topotecan is a medicine in the class oncology. It is used for cervical cancer.
- 薬効分類: Oncology
- 効能・効果: cervical cancer
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- ATCコード
- L01CE01
- 一般的な剤形
- 注射剤, カプセル剤
- 一般的な規格
- 1 mg/ml, 4 mg
- 既知の相互作用
- 110 (併用禁忌: 1 · 重大: 24 · 中等度: 78 · 軽度: 7)
- 商品名
- 10
- 国・市場
- 5
何に使われるか
作用のしくみ
Binds to topoisomerase I to produce double-strand breaks in DNA
成人の通常用量（添付文書の要約）
Small Cell Lung Cancer: (IV Infusion) 1.5mg/m² IV qDay x5 days; repeat at 21-day cycles,
妊娠と授乳
- 妊娠
- Unsafe Can cause fetal harm: in rats and rabbits it caused embryo deaths and malformations (mainly eye) at about the clinical dose; no human data. Check pregnancy status; women use contraception during and for 6 months after, men for 3 months.
- 授乳
- Unsafe No human data; rat milk levels were up to 48 times plasma levels. Do not breastfeed during treatment and for 1 week after the last dose.
報告されている副作用
- Vomiting
- Nausea
- Anemia
- Neutropenia
- Pain
- Thrombocytopenia
注意が必要な方
- Fatal cases of interstitial lung disease have occurred; permanently discontinue for confirmed ILD
- If extravasation occurs, immediately stop administration and institute recommended management procedures; severe cases reported
- PO: If patient vomits after taking capsule, do NOT repeat dose
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (110)
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporin + Topotecan Major
- Cyclosporine + Topotecan Major
- Darunavir + Topotecan Major
- Deferiprone + Topotecan Major
- Dengue vaccine + Topotecan Major
- Etrasimod + Topotecan Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Topotecanの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Topotecan used for?
Topotecan is a medicine in the class oncology. It is used for Cervical cancer, Lung cancer, Ovarian cancer.
What side effects have been reported with Topotecan?
Vomiting, Nausea, Anemia, Neutropenia, Pain, Thrombocytopenia.
Can Topotecan be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: in rats and rabbits it caused embryo deaths and malformations (mainly eye) at about the clinical dose; no human data. Check pregnancy status; women use contraception during and for 6 months after, men for 3 months. Breastfeeding: Unsafe. No human data; rat milk levels were up to 48 times plasma levels. Do not breastfeed during treatment and for 1 week after the last dose.
What does Topotecan interact with?
MediHelp lists 110 known interactions for Topotecan. Contraindicated: 1 · Major: 24 · Moderate: 78 · Minor: 7. The most serious include Adenovirus types 4 and 7 live, Amiodarone, Cisplatin.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
