医薬品リファレンス
Etoposide
Etoposide is a medicine in the class oncology. It is used for lung cancer.
- 薬効分類: Oncology
- 効能・効果: lung cancer
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- 一般的な剤形
- 注射剤, カプセル剤, 点滴静注剤
- 一般的な規格
- 100 mg/5 ml, 100 mg, 50 mg
- 既知の相互作用
- 130 (併用禁忌: 2 · 重大: 10 · 中等度: 99 · 軽度: 19)
- 商品名
- 19
- 国・市場
- 4
何に使われるか
作用のしくみ
Appears to inhibit or alter DNA replication, induces G2-phase arrest & preferentially kills cells in G2 & late S phases
成人の通常用量（添付文書の要約）
Testicular Cancer: 50-100 mg/m²/day IV on days 1-5, OR 100 mg/m²/day IV on days 1, 3, 5 Repeat q3-4week
妊娠と授乳
- 妊娠
- Unsafe Can cause fetal harm: in animals it caused embryo death and malformations at doses below human doses; it acts on dividing cells. Avoid in pregnancy. Use effective contraception during treatment and for 6 months after the last dose (Avopef label).
- 授乳
- Unsafe Passes into milk. Most sources say do not breastfeed during chemotherapy. LactMed: with intermittent courses, breastfeeding might resume after a break (at least 24 to 72 hours after a dose); discuss with the oncology team.
報告されている副作用
- Vomiting
- Diarrhea
- Nausea
- Anorexia
- Leukopenia
- Alopecia
注意が必要な方
- Prescriber must consider benefits versus risk of therapy; if severe reactions occur, dose should be reduced or discontinued and appropriate corrective measures taken
- Patients with low serum albumin may be at increased risk for etoposide associated toxicities
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (130)
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Cyclosporine + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
- Etoposide + Idelalisib Major
- Etoposide + Levoketoconazole Major
- Etoposide + Olaparib Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Etoposideの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Etoposide used for?
Etoposide is a medicine in the class oncology. It is used for Lung cancer, Testicular cancer.
What side effects have been reported with Etoposide?
Vomiting, Diarrhea, Nausea, Anorexia, Leukopenia, Alopecia.
Can Etoposide be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: in animals it caused embryo death and malformations at doses below human doses; it acts on dividing cells. Avoid in pregnancy. Use effective contraception during treatment and for 6 months after the last dose (Avopef label). Breastfeeding: Unsafe. Passes into milk. Most sources say do not breastfeed during chemotherapy. LactMed: with intermittent courses, breastfeeding might resume after a break (at least 24 to 72 hours after a dose); discuss with the oncology team.
What does Etoposide interact with?
MediHelp lists 130 known interactions for Etoposide. Contraindicated: 2 · Major: 10 · Moderate: 99 · Minor: 19. The most serious include Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
