相互作用
Abciximab + Caplacizumab
重症度: 重大
Abciximab and Caplacizumab: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Caplacizumab blocks von Willebrand factor-platelet binding and abciximab blocks platelet aggregation, so combined use increases bleeding risk. Serious bleeding including mucosal and intracranial hemorrhage is possible.
この相互作用をわかりやすく説明すると
Abciximab and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Abciximab belongs to Cardiovascular; Caplacizumab belongs to Cardiovascular.
なぜ起こるのか
Additive inhibition of platelet adhesion (anti-vWF A1 domain) and aggregation (GP IIb/IIIa blockade).
対処法
Avoid the combination where possible; if necessary, monitor closely for bleeding and withhold caplacizumab if clinically significant bleeding occurs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AbciximabとCaplacizumabの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Abciximabのその他の相互作用
Caplacizumabのその他の相互作用
よくある質問
Can I take Abciximab with Caplacizumab?
MediHelp rates the interaction as major. Abciximab and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab blocks von Willebrand factor-platelet binding and abciximab blocks platelet aggregation, so combined use increases bleeding risk. Serious bleeding including mucosal and intracranial hemorrhage is possible.
How serious is the interaction between Abciximab and Caplacizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if necessary, monitor closely for bleeding and withhold caplacizumab if clinically significant bleeding occurs.
What other medicines interact with Abciximab?
MediHelp also lists interactions of Abciximab with, for example, Abrocitinib, Acalabrutinib, Acetylsalicylic acid. The full list is on the Abciximab page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
