医薬品リファレンス
Caplacizumab
Caplacizumab is a medicine in the class cardiovascular. It is used for thrombocytopenic purpura.
- 薬効分類: Cardiovascular
- 効能・効果: thrombocytopenic purpura
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Cardiovascular
- 一般的な規格
- 10 mg
- 既知の相互作用
- 19 (重大: 17 · 中等度: 2)
- 商品名
- 2
- 国・市場
- 2
何に使われるか
作用のしくみ
Targets the A1-domain of von Willebrand factor (vWF) and inhibits the interaction between vWF and platelets, reducing vWF-mediated platelet adhesion and platelet consumption.
成人の通常用量（添付文書の要約）
aTTP, first day: 11 mg bolus intravenous injection at least 15 minutes prior to plasma exchange, then 11 mg subcutaneous injection after completion of plasma exchange on day 1
妊娠と授乳
- 妊娠
- Unknown No human data. It raises bleeding risk, so mother and fetus or newborn may bleed, especially around delivery. Guinea pig studies showed no developmental harm. Use if needed for TTP; monitor mother and newborn for bleeding.
- 授乳
- Unknown No milk data. LactMed: as a protein, milk levels are likely very low and it is probably digested in the infant gut; use with caution, especially with a newborn. Some advise not breastfeeding with acquired TTP. Weigh benefit.
報告されている副作用
- Epistaxis
- Headache
- Gingival bleeding
- Fatigue
- Urticaria
- Pyrexia
禁忌
- Previous severe hypersensitivity reaction to caplacizumab-yhdp or any of the excipients.
注意が必要な方
- Hemorrhage: serious and fatal bleeding can occur; risk increased with underlying coagulopathies or drugs affecting hemostasis. Interrupt if clinically significant bleeding occurs; von Willebrand factor concentrate may be given to correct hemostasis.
- Withhold for 7 days before elective surgery or invasive interventions; monitor closely for bleeding after resuming.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (19)
- Abciximab + Caplacizumab Major
- Acetylsalicylic acid + Caplacizumab Major
- Alteplase + Caplacizumab Major
- Anagrelide + Caplacizumab Major
- Apixaban + Caplacizumab Major
- Argatroban + Caplacizumab Major
- Caplacizumab + Clopidogrel Major
- Caplacizumab + Dabigatran etexilate Major
- Caplacizumab + Dalteparin Major
- Caplacizumab + Edoxaban Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Caplacizumabの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Caplacizumab used for?
Caplacizumab is a medicine in the class cardiovascular. It is used for Thrombocytopenic purpura.
What side effects have been reported with Caplacizumab?
Epistaxis, Headache, Gingival bleeding, Fatigue, Urticaria, Pyrexia.
Can Caplacizumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data. It raises bleeding risk, so mother and fetus or newborn may bleed, especially around delivery. Guinea pig studies showed no developmental harm. Use if needed for TTP; monitor mother and newborn for bleeding. Breastfeeding: Unknown. No milk data. LactMed: as a protein, milk levels are likely very low and it is probably digested in the infant gut; use with caution, especially with a newborn. Some advise not breastfeeding with acquired TTP. Weigh benefit.
What does Caplacizumab interact with?
MediHelp lists 19 known interactions for Caplacizumab. Major: 17 · Moderate: 2. The most serious include Abciximab, Acetylsalicylic acid, Alteplase.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
