相互作用
Argatroban + Caplacizumab
重症度: 重大
Argatroban and Caplacizumab: major interaction.
最終更新日
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概要
Caplacizumab inhibits von Willebrand factor-mediated platelet adhesion and argatroban inhibits thrombin, so the combination increases the risk of bleeding.
この相互作用をわかりやすく説明すると
Argatroban and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Argatroban belongs to Cardiovascular; Caplacizumab belongs to Cardiovascular.
なぜ起こるのか
Additive pharmacodynamic effect on hemostasis through antiplatelet adhesion and anticoagulant actions.
対処法
Avoid the combination unless benefit outweighs risk. If it is used, monitor aPTT and closely watch for bleeding, and consider holding caplacizumab if serious bleeding occurs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ArgatrobanとCaplacizumabの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Argatrobanのその他の相互作用
Caplacizumabのその他の相互作用
よくある質問
Can I take Argatroban with Caplacizumab?
MediHelp rates the interaction as major. Argatroban and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab inhibits von Willebrand factor-mediated platelet adhesion and argatroban inhibits thrombin, so the combination increases the risk of bleeding.
How serious is the interaction between Argatroban and Caplacizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless benefit outweighs risk. If it is used, monitor aPTT and closely watch for bleeding, and consider holding caplacizumab if serious bleeding occurs.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
