相互作用
Abiraterone + Rifapentine
重症度: 重大
Abiraterone and Rifapentine: major interaction.
最終更新日
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概要
Rifapentine induces CYP3A4 and is expected to lower abiraterone concentrations. This could reduce its effectiveness against prostate cancer.
この相互作用をわかりやすく説明すると
Abiraterone and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Abiraterone belongs to Endocrine; Rifapentine belongs to Anti Bacterial.
なぜ起こるのか
Rifapentine induces CYP3A4, accelerating abiraterone metabolism.
対処法
Avoid if possible. If required, increase abiraterone to twice daily during rifapentine therapy and monitor PSA and clinical response.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AbirateroneとRifapentineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Abirateroneのその他の相互作用
Rifapentineのその他の相互作用
よくある質問
Can I take Abiraterone with Rifapentine?
MediHelp rates the interaction as major. Abiraterone and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifapentine induces CYP3A4 and is expected to lower abiraterone concentrations. This could reduce its effectiveness against prostate cancer.
How serious is the interaction between Abiraterone and Rifapentine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If required, increase abiraterone to twice daily during rifapentine therapy and monitor PSA and clinical response.
What other medicines interact with Abiraterone?
MediHelp also lists interactions of Abiraterone with, for example, Radium-223 dichloride, Thioridazine, Amobarbital. The full list is on the Abiraterone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
