相互作用
Ranolazine + Rifapentine
重症度: 併用禁忌
Ranolazine and Rifapentine: contraindicated interaction.
最終更新日
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概要
Rifapentine is a strong CYP3A4 inducer and is expected to markedly lower ranolazine concentrations, causing loss of antianginal efficacy. Ranolazine labeling contraindicates CYP3A inducers.
この相互作用をわかりやすく説明すると
Ranolazine and Rifapentine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ranolazine belongs to Cardiovascular; Rifapentine belongs to Anti Bacterial.
なぜ起こるのか
Strong induction of CYP3A4 (and P-gp) increases ranolazine clearance.
対処法
Do not co-administer. Use an alternative antianginal during and shortly after rifapentine therapy.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、RanolazineとRifapentineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ranolazineのその他の相互作用
Rifapentineのその他の相互作用
よくある質問
Can I take Ranolazine with Rifapentine?
MediHelp rates the interaction as contraindicated. Ranolazine and Rifapentine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifapentine is a strong CYP3A4 inducer and is expected to markedly lower ranolazine concentrations, causing loss of antianginal efficacy. Ranolazine labeling contraindicates CYP3A inducers.
How serious is the interaction between Ranolazine and Rifapentine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use an alternative antianginal during and shortly after rifapentine therapy.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
