相互作用
Lurasidone + Rifapentine
重症度: 併用禁忌
Lurasidone and Rifapentine: contraindicated interaction.
最終更新日
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概要
Rifapentine induces CYP3A4 and can substantially lower lurasidone exposure. This may cause loss of antipsychotic efficacy and relapse. Strong CYP3A4 inducers are contraindicated with lurasidone.
この相互作用をわかりやすく説明すると
Lurasidone and Rifapentine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lurasidone belongs to Central Nervous System; Rifapentine belongs to Anti Bacterial.
なぜ起こるのか
Induction of CYP3A4 increases lurasidone clearance.
対処法
Avoid the combination; if rifapentine is required, use an antipsychotic less dependent on CYP3A4 and monitor psychiatric status.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、LurasidoneとRifapentineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lurasidoneのその他の相互作用
Rifapentineのその他の相互作用
よくある質問
Can I take Lurasidone with Rifapentine?
MediHelp rates the interaction as contraindicated. Lurasidone and Rifapentine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifapentine induces CYP3A4 and can substantially lower lurasidone exposure. This may cause loss of antipsychotic efficacy and relapse. Strong CYP3A4 inducers are contraindicated with lurasidone.
How serious is the interaction between Lurasidone and Rifapentine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if rifapentine is required, use an antipsychotic less dependent on CYP3A4 and monitor psychiatric status.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
