相互作用
Acalabrutinib + Ticagrelor
重症度: 重大
Acalabrutinib and Ticagrelor: major interaction.
最終更新日
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概要
Acalabrutinib impairs platelet function and is associated with bleeding and hemorrhage. Adding ticagrelor, a potent P2Y12 inhibitor, further raises bleeding risk including serious events.
この相互作用をわかりやすく説明すると
Acalabrutinib and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acalabrutinib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
なぜ起こるのか
Additive platelet inhibition from BTK inhibition and P2Y12 receptor blockade.
対処法
Monitor for bleeding and weigh the necessity of combined therapy. Consider holding acalabrutinib around surgery as per labeling.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AcalabrutinibとTicagrelorの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ticagrelorのその他の相互作用
Acalabrutinibのその他の相互作用
よくある質問
Can I take Acalabrutinib with Ticagrelor?
MediHelp rates the interaction as major. Acalabrutinib and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Acalabrutinib impairs platelet function and is associated with bleeding and hemorrhage. Adding ticagrelor, a potent P2Y12 inhibitor, further raises bleeding risk including serious events.
How serious is the interaction between Acalabrutinib and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and weigh the necessity of combined therapy. Consider holding acalabrutinib around surgery as per labeling.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
