相互作用
Itraconazole + Ticagrelor
重症度: 併用禁忌
Itraconazole and Ticagrelor: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Itraconazole is a strong CYP3A4 and P-glycoprotein inhibitor and raises ticagrelor exposure markedly. Bleeding risk and ticagrelor adverse effects, including dyspnoea, increase.
この相互作用をわかりやすく説明すると
Itraconazole and Ticagrelor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Itraconazole belongs to Anti Fungals; Ticagrelor belongs to Cardiovascular.
なぜ起こるのか
Strong CYP3A4/P-gp inhibition markedly raises ticagrelor exposure
対処法
Contraindicated; use an alternative P2Y12 inhibitor or antifungal.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ItraconazoleとTicagrelorの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Itraconazoleのその他の相互作用
Ticagrelorのその他の相互作用
よくある質問
Can I take Itraconazole with Ticagrelor?
MediHelp rates the interaction as contraindicated. Itraconazole and Ticagrelor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole is a strong CYP3A4 and P-glycoprotein inhibitor and raises ticagrelor exposure markedly. Bleeding risk and ticagrelor adverse effects, including dyspnoea, increase.
How serious is the interaction between Itraconazole and Ticagrelor?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; use an alternative P2Y12 inhibitor or antifungal.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
