医薬品リファレンス
Ticagrelor
Ticagrelor is a medicine in the class cardiovascular. It is used for acute coronary syndrome.
- 薬効分類: Cardiovascular
- 効能・効果: acute coronary syndrome
最終更新日
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要点
- 薬効分類
- Cardiovascular
- ATCコード
- B01AC24
- 一般的な剤形
- 錠剤
- 一般的な規格
- 90 mg, 60 mg
- 既知の相互作用
- 166 (併用禁忌: 3 · 重大: 80 · 中等度: 57 · 軽度: 26)
- 商品名
- 15
- 国・市場
- 6
何に使われるか
作用のしくみ
Ticagrelor and its major metabolite reversibly interact with the platelet P2Y12 ADP-receptor to prevent signal transduction and platelet activation, Ticagrelor and its active metabolite are approximately equipotent, Patients can be transitioned from clopidogrel to ticagrelor without interruption of antiplatelet effect
成人の通常用量（添付文書の要約）
Acute Coronary Syndrome or History of MI (Loading dose) (following ACS event): 180 mg PO x 1 dose
妊娠と授乳
- 妊娠
- Unknown Case reports have not shown a drug-related risk; in rats and rabbits it caused structural abnormalities at 5-7 times the human dose. UK label: not recommended in pregnancy; use contraception. If needed after a coronary stent, clopidogrel has more data; plan delivery around bleeding risk.
- 授乳
- Unknown No human milk data; it reaches rat milk at higher levels than plasma. US label: not recommended; UK: decide whether to stop breastfeeding or the drug. LactMed: over 99% protein bound, so milk levels are likely low; prefer an alternative, especially for a newborn; watch for bruising.
報告されている副作用
- Diarrhea
- Nausea
- Dizziness
- Dyspnea
- Bleeding
- Ventricular pauses
警告（枠囲み警告）
- Bleeding risk Like other antiplatelet agents, can cause significant, sometimes fatal, bleeding Do not use with active pathological bleeding or a history of intracranial hemorrhage Do not start in patients planned to undergo urgent coronary artery bypass graft surgery (CABG); when possible, discontinue at least 5 days prior to any surgery Suspect bleeding in any patient who is hypotensive and has recently undergone coronary angiography, percutaneous coronary intervention (PCI), CABG, or other surgical procedures after starting ticagrelor If possible, manage bleeding without disc…
禁忌
- History of intracranial hemorrhage (ICH)
- Active pathologic bleeding (eg, peptic ulcer, ICH)
注意が必要な方
- Avoid use with severe hepatic impairment, which may increase ticagrelor serum levels
- Reported to cause false-negative results in platelet functional tests (eg, HIPA assay for HIT)
- Can cause ventricular pauses; bradyarrhythmias, including AV block reported
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (166)
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
- Acetylsalicylic acid + Ticagrelor Major
- Alteplase + Ticagrelor Major
- Apalutamide + Ticagrelor Major
- Aspirin + Ticagrelor Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Ticagrelorの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Ticagrelor used for?
Ticagrelor is a medicine in the class cardiovascular. It is used for Acute coronary syndrome, Coronary artery disease, Myocardial infarction, Stroke, Transient ischemic attack.
What side effects have been reported with Ticagrelor?
Diarrhea, Nausea, Dizziness, Dyspnea, Bleeding, Ventricular pauses. Serious warning: Bleeding risk Like other antiplatelet agents, can cause significant, sometimes fatal, bleeding Do not use with active pathological bleeding or a history of intracranial hemorrhage Do not start in patients planned to undergo urgent coronary artery bypass graft surgery (CABG); when possible,…
Can Ticagrelor be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Case reports have not shown a drug-related risk; in rats and rabbits it caused structural abnormalities at 5-7 times the human dose. UK label: not recommended in pregnancy; use contraception. If needed after a coronary stent, clopidogrel has more data; plan delivery around bleeding risk. Breastfeeding: Unknown. No human milk data; it reaches rat milk at higher levels than plasma. US label: not recommended; UK: decide whether to stop breastfeeding or the drug. LactMed: over 99% protein bound, so milk levels are likely low; prefer an alternative, especially for a newborn; watch for bruising.
What does Ticagrelor interact with?
MediHelp lists 166 known interactions for Ticagrelor. Contraindicated: 3 · Major: 80 · Moderate: 57 · Minor: 26. The most serious include Itraconazole, Ketoconazole, Levoketoconazole.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
