相互作用
Acetylsalicylic acid + Ticagrelor
重症度: 重大
Acetylsalicylic acid and Ticagrelor: major interaction.
最終更新日
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概要
Maintenance aspirin doses above 100 mg daily reduce the clinical benefit of ticagrelor, with worse cardiovascular outcomes seen. The combination is standard with low-dose aspirin, but bleeding risk is additive.
この相互作用をわかりやすく説明すると
Acetylsalicylic acid and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Ticagrelor belongs to Cardiovascular.
なぜ起こるのか
Additive platelet inhibition increases bleeding, and higher aspirin doses appear to diminish ticagrelor efficacy through a mechanism that is not fully understood.
対処法
Keep maintenance aspirin at 75-100 mg daily after any initial loading dose. Monitor for bleeding.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Acetylsalicylic acidとTicagrelorの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Acetylsalicylic acidのその他の相互作用
Ticagrelorのその他の相互作用
よくある質問
Can I take Acetylsalicylic acid with Ticagrelor?
MediHelp rates the interaction as major. Acetylsalicylic acid and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Maintenance aspirin doses above 100 mg daily reduce the clinical benefit of ticagrelor, with worse cardiovascular outcomes seen. The combination is standard with low-dose aspirin, but bleeding risk is additive.
How serious is the interaction between Acetylsalicylic acid and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep maintenance aspirin at 75-100 mg daily after any initial loading dose. Monitor for bleeding.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
