相互作用
Acetylcysteine + Nitroglycerin
重症度: 中等度
Acetylcysteine and Nitroglycerin: moderate interaction.
最終更新日
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概要
Acetylcysteine may potentiate the vasodilating effect of nitroglycerin, with possible hypotension and headache. The effect is mainly described with intravenous nitroglycerin.
この相互作用をわかりやすく説明すると
Acetylcysteine and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylcysteine belongs to Respiratory; Nitroglycerin belongs to Cardiovascular.
なぜ起こるのか
Acetylcysteine supplies thiol groups that may enhance nitroglycerin bioactivation and nitric oxide-mediated vasodilation.
対処法
Monitor blood pressure and headache when acetylcysteine is given with intravenous nitroglycerin, and reduce the nitroglycerin infusion rate if hypotension occurs.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AcetylcysteineとNitroglycerinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Acetylcysteineのその他の相互作用
Nitroglycerinのその他の相互作用
よくある質問
Can I take Acetylcysteine with Nitroglycerin?
MediHelp rates the interaction as moderate. Acetylcysteine and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Acetylcysteine may potentiate the vasodilating effect of nitroglycerin, with possible hypotension and headache. The effect is mainly described with intravenous nitroglycerin.
How serious is the interaction between Acetylcysteine and Nitroglycerin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and headache when acetylcysteine is given with intravenous nitroglycerin, and reduce the nitroglycerin infusion rate if hypotension occurs.
What other medicines interact with Acetylcysteine?
MediHelp also lists interactions of Acetylcysteine with, for example, Nitroglycerin po, Nitroglycerin rectal, Nitroglycerin sublingual. The full list is on the Acetylcysteine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
