相互作用
Nitroglycerin + Tadalafil
重症度: 併用禁忌
Nitroglycerin and Tadalafil: contraindicated interaction.
最終更新日 出典: US FDA label
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概要
Tadalafil potentiates the hypotensive effect of nitrates and the combination can cause severe, potentially fatal hypotension, syncope or myocardial ischaemia. Because of tadalafil's long half-life, the risk persists for a prolonged period after a dose. Use is contraindicated in labeling.
この相互作用をわかりやすく説明すると
Nitroglycerin and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nitroglycerin belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
なぜ起こるのか
PDE5 inhibition prevents cGMP breakdown while nitroglycerin raises cGMP via nitric oxide, producing exaggerated vasodilation.
対処法
Do not use nitrates in patients who have taken tadalafil in the previous 48 hours. If a nitrate is needed urgently after that interval, use it only under close medical supervision.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、NitroglycerinとTadalafilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
- Cialis (tadalafil) Prescribing Information - Contraindications — FDA Label
- Cialis SmPC - Contraindications — EMA SmPC
Tadalafilのその他の相互作用
Nitroglycerinのその他の相互作用
よくある質問
Can I take Nitroglycerin with Tadalafil?
MediHelp rates the interaction as contraindicated. Nitroglycerin and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tadalafil potentiates the hypotensive effect of nitrates and the combination can cause severe, potentially fatal hypotension, syncope or myocardial ischaemia. Because of tadalafil's long half-life, the risk persists for a prolonged period after a dose. Use is contraindicated in labeling.
How serious is the interaction between Nitroglycerin and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use nitrates in patients who have taken tadalafil in the previous 48 hours. If a nitrate is needed urgently after that interval, use it only under close medical supervision.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
