相互作用
Nitroglycerin + Riociguat
重症度: 併用禁忌
Nitroglycerin and Riociguat: contraindicated interaction.
最終更新日
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概要
Riociguat stimulates soluble guanylate cyclase and nitrates supply nitric oxide, producing additive vasodilation. Severe, potentially life-threatening hypotension can result. Labeling contraindicates concomitant use of riociguat with nitrates in any form.
この相互作用をわかりやすく説明すると
Nitroglycerin and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nitroglycerin belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
なぜ起こるのか
Additive cGMP-mediated vasodilation from nitric oxide donation and soluble guanylate cyclase stimulation.
対処法
Do not co-administer. Use a non-nitrate option for angina or acute needs while on riociguat.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、NitroglycerinとRiociguatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Nitroglycerinのその他の相互作用
Riociguatのその他の相互作用
よくある質問
Can I take Nitroglycerin with Riociguat?
MediHelp rates the interaction as contraindicated. Nitroglycerin and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Riociguat stimulates soluble guanylate cyclase and nitrates supply nitric oxide, producing additive vasodilation. Severe, potentially life-threatening hypotension can result. Labeling contraindicates concomitant use of riociguat with nitrates in any form.
How serious is the interaction between Nitroglycerin and Riociguat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use a non-nitrate option for angina or acute needs while on riociguat.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Sildenafil, Tadalafil. The full list is on the Nitroglycerin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
