相互作用
Acetylsalicylic acid + Bismuth subsalicylate
重症度: 中等度
Acetylsalicylic acid and Bismuth subsalicylate: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Bismuth subsalicylate is hydrolysed to release salicylate, so taking it with aspirin adds to the total salicylate load. This can raise the risk of salicylate toxicity such as tinnitus and gastrointestinal bleeding, especially with repeated or high dosing.
この相互作用をわかりやすく説明すると
Acetylsalicylic acid and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Bismuth subsalicylate belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive salicylate exposure and additive antiplatelet and gastrointestinal mucosal effects.
対処法
Avoid routine concurrent use of bismuth subsalicylate with analgesic-dose aspirin and limit duration. Monitor for tinnitus, GI bleeding and bruising, particularly in older adults and those on anticoagulants.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Acetylsalicylic acidとBismuth subsalicylateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Acetylsalicylic acidのその他の相互作用
Bismuth subsalicylateのその他の相互作用
よくある質問
Can I take Acetylsalicylic acid with Bismuth subsalicylate?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bismuth subsalicylate is hydrolysed to release salicylate, so taking it with aspirin adds to the total salicylate load. This can raise the risk of salicylate toxicity such as tinnitus and gastrointestinal bleeding, especially with repeated or high dosing.
How serious is the interaction between Acetylsalicylic acid and Bismuth subsalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of bismuth subsalicylate with analgesic-dose aspirin and limit duration. Monitor for tinnitus, GI bleeding and bruising, particularly in older adults and those on anticoagulants.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
