相互作用
Amlodipine-benazepril + Bismuth subsalicylate
重症度: 中等度
Amlodipine-benazepril and Bismuth subsalicylate: moderate interaction.
最終更新日
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概要
Bismuth subsalicylate releases salicylate, which can blunt the antihypertensive effect of benazepril and may add to renal risk. The effect is mainly relevant with frequent or prolonged use, or in dehydrated or renally impaired patients.
この相互作用をわかりやすく説明すると
Amlodipine-benazepril and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Bismuth subsalicylate belongs to Gastrointestinal Tract.
なぜ起こるのか
Salicylate inhibits prostaglandin synthesis, reducing renal vasodilation and sodium excretion and opposing ACE inhibitor effects.
対処法
Limit bismuth subsalicylate to short-term use and avoid it in renal impairment or dehydration. Monitor blood pressure and renal function if use is prolonged.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amlodipine-benazeprilとBismuth subsalicylateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-benazeprilのその他の相互作用
Bismuth subsalicylateのその他の相互作用
よくある質問
Can I take Amlodipine-benazepril with Bismuth subsalicylate?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bismuth subsalicylate releases salicylate, which can blunt the antihypertensive effect of benazepril and may add to renal risk. The effect is mainly relevant with frequent or prolonged use, or in dehydrated or renally impaired patients.
How serious is the interaction between Amlodipine-benazepril and Bismuth subsalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit bismuth subsalicylate to short-term use and avoid it in renal impairment or dehydration. Monitor blood pressure and renal function if use is prolonged.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
