相互作用
Bismuth subsalicylate + Dichlorphenamide
重症度: 重大
Bismuth subsalicylate and Dichlorphenamide: major interaction.
最終更新日
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概要
Bismuth subsalicylate is hydrolysed to salicylate, and dichlorphenamide is a carbonic anhydrase inhibitor; with salicylates it can accumulate salicylate and worsen metabolic acidosis. Tachypnoea, lethargy and coma have been reported with high-dose aspirin.
この相互作用をわかりやすく説明すると
Bismuth subsalicylate and Dichlorphenamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bismuth subsalicylate belongs to Gastrointestinal Tract; Dichlorphenamide belongs to Miscellaneous.
なぜ起こるのか
Carbonic anhydrase inhibition causes metabolic acidosis and reduced salicylate renal clearance, raising salicylate levels
対処法
Avoid bismuth subsalicylate during dichlorphenamide therapy; if salicylate is needed use lowest dose and monitor acid-base status and symptoms of salicylism.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Bismuth subsalicylateとDichlorphenamideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Bismuth subsalicylateのその他の相互作用
Dichlorphenamideのその他の相互作用
よくある質問
Can I take Bismuth subsalicylate with Dichlorphenamide?
MediHelp rates the interaction as major. Bismuth subsalicylate and Dichlorphenamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bismuth subsalicylate is hydrolysed to salicylate, and dichlorphenamide is a carbonic anhydrase inhibitor; with salicylates it can accumulate salicylate and worsen metabolic acidosis. Tachypnoea, lethargy and coma have been reported with high-dose aspirin.
How serious is the interaction between Bismuth subsalicylate and Dichlorphenamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid bismuth subsalicylate during dichlorphenamide therapy; if salicylate is needed use lowest dose and monitor acid-base status and symptoms of salicylism.
What other medicines interact with Bismuth subsalicylate?
MediHelp also lists interactions of Bismuth subsalicylate with, for example, Warfarin, Acetylsalicylic acid, Amlodipine-benazepril. The full list is on the Bismuth subsalicylate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
