相互作用
Alfentanil + Brexpiprazole
重症度: 重大
Alfentanil and Brexpiprazole: major interaction.
最終更新日
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概要
Opioids combined with other CNS depressants can cause profound sedation, respiratory depression, hypotension, coma and death. Brexpiprazole adds sedative and orthostatic effects to alfentanil.
この相互作用をわかりやすく説明すると
Alfentanil and Brexpiprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS and respiratory depression.
対処法
Use together only when alternative options are inadequate, with the lowest effective doses and shortest duration. Monitor for sedation, respiratory depression and hypotension.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AlfentanilとBrexpiprazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Brexpiprazoleのその他の相互作用
よくある質問
Can I take Alfentanil with Brexpiprazole?
MediHelp rates the interaction as major. Alfentanil and Brexpiprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with other CNS depressants can cause profound sedation, respiratory depression, hypotension, coma and death. Brexpiprazole adds sedative and orthostatic effects to alfentanil.
How serious is the interaction between Alfentanil and Brexpiprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when alternative options are inadequate, with the lowest effective doses and shortest duration. Monitor for sedation, respiratory depression and hypotension.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Amisulpride, Apalutamide, Atazanavir. The full list is on the Brexpiprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
