相互作用
Apalutamide + Brexpiprazole
重症度: 重大
Apalutamide and Brexpiprazole: major interaction.
最終更新日
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概要
Apalutamide is a strong CYP3A4 inducer and lowers brexpiprazole exposure, since brexpiprazole is cleared by CYP3A4 and CYP2D6. This can lead to loss of antipsychotic efficacy and relapse.
この相互作用をわかりやすく説明すると
Apalutamide and Brexpiprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Brexpiprazole belongs to Central Nervous System.
なぜ起こるのか
Induction of CYP3A4 by apalutamide increases brexpiprazole metabolism and lowers plasma concentrations.
対処法
Brexpiprazole labeling advises doubling the dose when a strong CYP3A4 inducer is added, with reduction back to the usual dose if the inducer is stopped. Monitor clinical response, or consider an alternative to apalutamide where possible.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApalutamideとBrexpiprazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Brexpiprazoleのその他の相互作用
Apalutamideのその他の相互作用
よくある質問
Can I take Apalutamide with Brexpiprazole?
MediHelp rates the interaction as major. Apalutamide and Brexpiprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong CYP3A4 inducer and lowers brexpiprazole exposure, since brexpiprazole is cleared by CYP3A4 and CYP2D6. This can lead to loss of antipsychotic efficacy and relapse.
How serious is the interaction between Apalutamide and Brexpiprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Brexpiprazole labeling advises doubling the dose when a strong CYP3A4 inducer is added, with reduction back to the usual dose if the inducer is stopped. Monitor clinical response, or consider an alternative to apalutamide where possible.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Atazanavir. The full list is on the Brexpiprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
