相互作用
Brexpiprazole + Buprenorphine buccal
重症度: 重大
Brexpiprazole and Buprenorphine buccal: major interaction.
最終更新日
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概要
Using brexpiprazole with buccal buprenorphine may cause additive drowsiness and slowed breathing. Cognitive and motor impairment can also be increased.
この相互作用をわかりやすく説明すると
Brexpiprazole and Buprenorphine buccal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS depression between an opioid partial agonist and a sedating antipsychotic.
対処法
Use only if alternatives are inadequate, keep doses low, and monitor for excessive sedation and respiratory depression, especially at initiation and after dose changes.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BrexpiprazoleとBuprenorphine buccalの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Brexpiprazoleのその他の相互作用
よくある質問
Can I take Brexpiprazole with Buprenorphine buccal?
MediHelp rates the interaction as major. Brexpiprazole and Buprenorphine buccal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using brexpiprazole with buccal buprenorphine may cause additive drowsiness and slowed breathing. Cognitive and motor impairment can also be increased.
How serious is the interaction between Brexpiprazole and Buprenorphine buccal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if alternatives are inadequate, keep doses low, and monitor for excessive sedation and respiratory depression, especially at initiation and after dose changes.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
