相互作用
Benzhydrocodone / acetaminophen + Brexpiprazole
重症度: 重大
Benzhydrocodone / acetaminophen and Brexpiprazole: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Brexpiprazole combined with an opioid such as benzhydrocodone can produce additive sedation, dizziness and impaired psychomotor performance. Opioid-related respiratory depression may be worsened by other CNS depressants.
この相互作用をわかりやすく説明すると
Benzhydrocodone / acetaminophen and Brexpiprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive central nervous system depression from opioid agonism and the antihistaminic and antiadrenergic effects of brexpiprazole.
対処法
Reserve the combination for patients in whom alternatives are inadequate, use the lowest effective doses for the shortest duration, and monitor for sedation and respiratory depression.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Benzhydrocodone / acetaminophenとBrexpiprazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Brexpiprazoleのその他の相互作用
よくある質問
Can I take Benzhydrocodone / acetaminophen with Brexpiprazole?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Brexpiprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexpiprazole combined with an opioid such as benzhydrocodone can produce additive sedation, dizziness and impaired psychomotor performance. Opioid-related respiratory depression may be worsened by other CNS depressants.
How serious is the interaction between Benzhydrocodone / acetaminophen and Brexpiprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients in whom alternatives are inadequate, use the lowest effective doses for the shortest duration, and monitor for sedation and respiratory depression.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
