相互作用
Allopurinol + Valoctocogene roxaparvovec
重症度: 中等度
Allopurinol and Valoctocogene roxaparvovec: moderate interaction.
最終更新日
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概要
Valoctocogene roxaparvovec is a liver-directed gene therapy that commonly causes ALT elevations. Hepatotoxic drugs, including allopurinol which can occasionally cause hepatitis, may increase the risk of liver injury and confound interpretation of enzyme rises.
この相互作用をわかりやすく説明すると
Allopurinol and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Allopurinol belongs to Genitourinary; Valoctocogene roxaparvovec belongs to Miscellaneous.
なぜ起こるのか
Additive hepatotoxic potential in a liver transduced by AAV gene therapy; no pharmacokinetic mechanism is established.
対処法
Monitor ALT regularly after infusion as per product labeling and review necessity of allopurinol. Consider alternatives if liver enzymes rise.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AllopurinolとValoctocogene roxaparvovecの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Allopurinolのその他の相互作用
Valoctocogene roxaparvovecのその他の相互作用
よくある質問
Can I take Allopurinol with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Allopurinol and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec is a liver-directed gene therapy that commonly causes ALT elevations. Hepatotoxic drugs, including allopurinol which can occasionally cause hepatitis, may increase the risk of liver injury and confound interpretation of enzyme rises.
How serious is the interaction between Allopurinol and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT regularly after infusion as per product labeling and review necessity of allopurinol. Consider alternatives if liver enzymes rise.
What other medicines interact with Allopurinol?
MediHelp also lists interactions of Allopurinol with, for example, Azathioprine, Didanosine, Mercaptopurine. The full list is on the Allopurinol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
